Tri-Institutional Training in Vision Research

描述(由申请人提供)：康奈尔大学威尔医学院(前身为康奈尔大学医学院)、斯隆·凯特林研究所和洛克菲勒大学三所相邻机构的教职员工申请资金，以继续九年前开始的视觉研究三机构合作培训计划。目前的TTPVR包括一套针对博士生、博士后研究员和医学生的综合培训活动。这些机构的优势和多样性为研究视网膜细胞和发育生物学、遗传学、吞噬作用、分泌和内吞作用、神经再生、发育和可塑性、信号转导以及眼睛和大脑水平的信息处理提供了机会。各种研究项目利用了大量的方法，如分子和细胞生物学、酵母和小鼠遗传学、基因转移和治疗、电生理学、成像、高分辨率光学显微镜、行为学、模型学和流行病学。视力培训资源的汇集导致了除个别机构现有课程之外的更多课程的丰富，促进了参与的基础科学教师之间以及与临床教师之间的合作，并为聘用新的视觉学院或吸引现有教师进入视觉研究提供了独特的机会。项目教职员工和学生之间的互动通过愿景研讨会进行 系列和视觉杂志俱乐部，这是Arvo后的年度海报会议，通过临床学术教师设计的课程，让基础视觉科学家接触临床上看到的视力障碍，以及涉及视觉研究的各个方面的课程。这种接触为更敏锐地了解临床问题和选择研究领域提供了一种工具，这些研究领域将临床和基础科学家联合起来，寻求治愈致盲疾病。请求NIH支持拟议的视觉研究三机构培训计划是基于参与机构对致力于视觉研究的教师、资金和研究空间的重大承诺。

DESCRIPTION (provided by applicant): Faculty of three contiguous institutions, Weill Medical College of Cornell University (formerly Cornell University Medical College), Sloan Kettering Institute, and The Rockefeller University, request funds to continue a collaborative tri-institutional training program in vision research started nine years ago. The current TTPVR consists of an integrated set of training activities for PhD students, postdoctoral fellows and medical students. The strengths and diversities of the faculties provide opportunities for research in retinal cell and developmental biology, genetics, phagocytosis, secretion and endocytosis, neural regeneration, development and plasticity, signal transduction, and information processing at the level of the eye and the brain. The various research projects utilize a vast array of methodologies, such as molecular and cell biology, yeast and mouse genetics, gene transfer and therapy, electrophysiology, imaging, high resolution optical microscopy, behavior, modeling, and epidemiology. The pooling of resources for vision training leads to an enrichment of programs over and above those available at the individual institutions, promotes collaborations between participating basic science faculty, as well as with clinical faculty, and provides a unique opportunity for the hiring of new Vision Faculty or attracting existing faculty into Vision Research. Interaction between Program Faculty and students takes place via a Vision seminar series and a Vision journal club, an annual post-ARVO poster session, through a course by clinical-academic faculty designed to expose basic vision scientists to vision disorders seen in the clinic and courses dealing with various aspects of vision research. This exposure provides a vehicle for a keener understanding of clinical problems and for the selection of research areas that unite clinical and basic scientists in the quest to cure blinding diseases. The request for NIH support of a proposed Tri-Institutional Training Program in Vision Research builds on major commitments by the participating institutions of faculty, funds and research space devoted to vision research.