Tri-Institutional Training Program in Laboratory Animal Medicine and Science

描述（由申请人提供）：纪念斯隆-凯特琳癌症中心，洛克菲勒大学和威尔康奈尔医学院正在寻求联邦资金，以支持三名学员在他们的三机构培训计划在实验动物医学和科学（TTP-LAMS）。培训计划的结构和研究环境和设施用于培训是独一无二的，无与伦比的。学员由经验丰富的TTP-LAMS计划教师指导，包括董事会认证的实验室动物兽医（6）和比较病理学家（3），以及生物医学成像，动物园运营和管理，法规事务，单克隆抗体生产和基因靶向方面的专家。受训人员接触到世界一流的教师在不同的科学学科进行生物医学研究。三机构的教师是世界上最杰出的医学和生物医学科学家之一。这三个机构是超过37名国家科学院成员和8名诺贝尔奖获得者的家园，每年获得900多个NIH奖项，总额约3亿美元。在14个最先进的三机构动物园内进行培训，其中平均每天对代表14个物种的超过300，000只动物进行普查。比较病理学的多学科实验室，提供解剖和临床病理学服务，以及各种研究核心设施是在学员的处置。为期3年的TTP-LAMS计划分为两个主要组成部分：经验和教学。体验部分分为两个主要领域：临床，管理和行政培训（CMAT）和独立的研究培训。CMAT向学员介绍学术动物资源计划管理和操作的各个方面，以及实验动物物种的临床护理和研究利用。在93周内完成了9个不同长度的CMAT旋转。研究培训（63周）为学员提供了将科学方法应用于基础或临床研究项目的机会，并培养了对科学发现过程的欣赏。教学培训包括完成威尔康奈尔大学医学研究生院提供的研究生课程，参加各种课程，包括每周一次的临床和病理学会议和实验室动物医学和科学研讨会系列（提供约230小时的总接触时间），以及每两周一次的生物安全案例会议和期刊俱乐部。 公共卫生相关性：实验室动物对美国的基础和转化生物医学研究活动至关重要。在许多科学学科中利用实验室动物所取得的发现，对人类和动物的健康和福利产生了无数深远的改善。实验室动物兽医作为这一关键资源的管理员，提供必要的专业知识，以确保动物的健康和福祉。在美国的兽医学院和学校里，实验动物医学的培训充其量是粗略的。寻求这一学科专业知识的兽医通常在学术，政府或制药生物医学研究中心完成研究生专业培训，其中实验室动物用于支持研究企业。该奖项将允许由纪念斯隆-凯特琳癌症中心、洛克菲勒大学和威尔康奈尔医学院组成的三机构财团为三名兽医提供实验室动物医学的研究生专业培训。

DESCRIPTION (provided by applicant): The Memorial Sloan-Kettering Cancer Center, The Rockefeller University, and the Weill Cornell Medical College are seeking federal funding to support three trainees in their Tri-Institutional Training Program in Laboratory Animal Medicine and Science (TTP-LAMS). The training program structure and the research environment and facilities utilized for training are unique and unparalleled. Trainees are mentored by highly experienced TTP-LAMS program faculty including board-certified laboratory animal veterinarians (6) and comparative pathologists (3), as well as specialists in biomedical imaging, vivarium operations and administration, regulatory affairs, monoclonal antibody production, and gene-targeting. Trainees are exposed to world-class faculty conducting biomedical research in diverse scientific disciplines. The tri-institutional faculty is among the most distinguished medicl and biomedical scientists in the world. The three institutions are the home for more than 37 members of the National Academy of Sciences and 8 Nobel laureates receiving more than 900 NIH awards totalling ~$ 300 M annually. Training is conducted within 14 state-of-the-art tri- institutional vivaria in which an average daily census of greater than 300,000 animals representing 14 species is maintained. The multi-disciplinary Laboratory of Comparative Pathology, providing anatomic and clinical pathology services, and various research core facilities are at the disposal of the trainee. The 3-year TTP- LAMS program is divided into two principal components: experiential and didactic. The experiential component is divided into two principal areas: Clinical, Management, and Administrative Training (CMAT) and independent Research Training. CMAT introduces trainees to all aspects of academic animal resource program management and operations as well as the clinical care and research utilization of laboratory animal species. There are nine CMAT rotations of varying lengths completed during 93 weeks. Research training (63 weeks) provides trainees the opportunity to apply the scientific method to a basic or clinical research project and to develop an appreciation for the process of scientific discovery. Didactic training includes the completion of graduate level courses offered by the Weill Cornell Graduate School of Medical Sciences, attending various program sessions including weekly a clinical and pathology conference and a laboratory animal medicine and science seminar series (providing ~ 230 h total contact time), as well as biweekly biosecurity case conferences and journal club. PUBLIC HEALTH RELEVANCE: Laboratory animals are vital to basic and translational biomedical research activities in the United States. The discoveries made utilizing laboratory animals in numerous scientific disciplines have resulted in countless and far-reaching improvements to human as well as animal health and welfare. Laboratory animal veterinarians serve as stewards for this critical resource providing the necessary expertise to ensure the animals' health and well-being. Training in laboratory animal medicine is cursory, at best, in America's colleges and schools of veterinary medicine. Veterinarians seeking expertise in this discipline generally complete post- graduate specialty training at an academic, government or pharmaceutical biomedical research center in which laboratory animals are used in support of the research enterprise. This award will allow the tri-institutional consortium, consisting of the Memorial Sloan-Kettering Cancer Center, The Rockefeller University, and the Weill Cornell Medical College to provide post- graduate specialty training in laboratory animal medicine to three veterinarians.