Exploring the Heterogeneous Biogenesis Pathways of the Bacterial Cell Envelope.

细胞膜是细菌防御和致病的前线。关键的蛋白质组件是成熟、定位和组装细胞周围的蛋白质、糖和脂肪所必需的，以实现对抗生素、噬菌体和毒素的保护，并调节细胞结构和形状。它的一个主要组成部分是基本的胞外细胞壁，它在细胞周围形成一层网状的外衣。它的组装是许多抗生素的靶标。在这里，我们将使用分子模拟来研究负责细胞壁的形成和细胞膜内其他生物发生途径的蛋白质机制。

The cell envelope serves as the front-line to both defence and pathogenicity in bacteria. Critical protein assemblies are required to mature, localise and assemble proteins, sugars and lipids around the cell to enable protection against antibiotics, phages and toxins, and to modulate cell structure and shape. A major component of this is the essential extracellular cell wall, which forms a mesh-like coat around the cell. Its assembly is the target for many antibiotics. Here we will use molecular simulation to study the protein machinery responsible for the formation of the cell wall and other biogenesis pathways within the cell envelope.