New approaches to combating drug resistance via saturated chemical architectures

在这个合成化学项目中，我们研究了取代芳香族药效团饱和烃框架的可行性，作为发现不太可能诱导耐药性的新治疗剂的一种手段。随着对标准治疗方案反应不佳的疾病的出现，耐药性是一个日益严重的健康和经济问题。有许多方式可以引起耐药性和药物失活。开发克服这些途径的药物是当今的一个关键挑战。本项目的目标是开发新的合成方法，用于饱和烃基序的化学合成，以扩大饱和笼状烃的可及化学空间。将设计含苯药物的类似物，以评估这些结构修饰如何影响失活代谢途径。该技术不仅在新药开发方面具有潜在的应用前景，而且在新型聚合物、含能材料和催化剂的创新方面也具有潜在的应用前景。

In this synthetic chemistry project we examine the feasibility of replacing aromatic pharmacophores saturated hydrocarbon frameworks as a means of discovering new therapeutic agents that are less likely to induce drug resistance. Drug resistance is an increasing health and economic concern with the emergence of diseases that respond poorly to standard treatment regimes. There are numerous ways by which drug resistance and drug deactivation can arise. The development of drugs that overcome these pathways is a key challenge today. The aims of this project are to develop new synthetic methods for the chemical synthesis of saturated hydrocarbon motifs to expand the accessible chemical space of saturated caged-hydrocarbons. Analogues of benzene-containing pharmaceuticals will be devised to assess how these structural modifications affect deactivating metabolic pathways. This technology does not only has potential applications in the development of new medicines, but also for the innovation of novel polymers, energetic materials and catalysts.