CRISPR-Cas9 genetic screens for therapeutic targets against oxidative stress in Parkinson's disease

人类的发育始于受孕后，从一个细胞球开始，最终形成人体的复杂结构。这些细胞中的一部分是干细胞，具有分化成许多不同细胞类型的能力的多能细胞。成体干细胞在补充死亡细胞和修复受损组织方面至关重要。干细胞作为模拟复杂生物系统和疾病的多功能工具，也彻底改变了生物学研究。主要的兴趣是了解干细胞生物学的机制，利用这个系统来开发复杂的基于干细胞的方法来模拟复杂的疾病。细胞疗法作为再生医学的一种方式的前景现在也日益成为现实。

Human development begins post conception from merely a ball of cells that eventually forms the complex architecture of the human body. A proportion of these cells are stem cells, pluripotent cells with the capacity to differentiateinto many different cell types. Adult stem cells are vital in replenishing dying cells and repairing damaged tissues. Stem cells have also revolutionised biological research as a versatile tool to model complex biological systemsand diseases. Primary interest is understanding the mechanisms of stem cell biology to exploit this system to develop sophisticated stem cell-based approaches to model complex diseases. The prospect of cell-based therapy as a modality of regenerative medicine is now also becoming a tangible reality by the day.