Novel Chemoenzymatic Approaches to 'Unnatural' Products

“许多抗癌、抗生素、抗寄生虫和抗病毒剂的天然产物在微生物中由多功能酶如聚酮酶（PKS）和非核糖体肽合成酶（NRPS）生物合成。这些天然存在的“分子工厂”被视为有希望的起点，用于开发化学酶途径，以产生“非天然”产物-分子仍然通过生物合成产生，但结构上不同于原始产物，可能具有同等或上级价值。本博士项目的目的是开发新的化学酶方法，以体外产生非天然产物：通过利用化学工具和工程酶/途径，我们的目标是产生具有制药和工业价值的新型化合物库。"

"Many natural products of anticancer, antibiotic, antiparasitic and antiviral agents, amongst others, are biosynthesised in microorganisms by multifunctional enzymes, such as the polyketide synthases (PKSs) and the nonribosomal peptide synthetases (NRPSs). These naturally occurring 'molecular factories' are seen as the promising starting point for the development of chemoenzymatic routes towards the generation of 'unnatural' product- molecules that are still produced via biosynthesis but that are structurally different from the original products and may be of equal or superior value.The aim of this PhD project is to develop novel chemoenzymatic approaches towards the in vitro generation of unnatural products: by utilising chemical tools and engineered enzymes/pathways, we aim at generating libraries of novel compounds of pharmaceutical and industrial interest."