Development of Chemoenzymatic Approaches to Bioactive Molecules

这项研究的重点是关键步骤中酶的使用 复杂分子的合成。 所提出的基质 因为酶是内消旋化合物， 简单的环状烃的氧化 环戊二烯、苯、环庚三烯、环庚烯和 1，5-环辛二烯。 酶促反应将用于 揭示了多个手性中心。由此产生的积木 将接触到一些合成协议，包括 使用过渡金属催化的偶联反应， 给出了不同种类的生物分子。 %%% 有了这个基于成就的更新奖，合成 有机计划是支持博士卡尔R。 韦恩州立大学化学系的约翰逊说 大学 约翰逊教授将把工作重点放在 酶作为催化剂在生物合成关键步骤中的应用 复杂有机分子的合成。

The focus of this research is the use of enzymes in key steps of the synthesis of complex molecules. The proposed substrates for the enzymes are meso compounds readily available from the oxidation of simple cyclic hydrocarbons such as cyclopentadiene, benzene, cycloheptatriene, cycloheptene and 1,5-cyclooctadiene. The enzymatic reactions will serve to unveil multiple chiral centers. The resulting building blocks will be exposed to a number of synthetic protocols,including the use of transition metal-catalyzed coupling reactions, to give various classes of molecules of biological interest. %%% With this Accomplishment Based Renewal award, the Synthetic Organic Program is supporting the research of Dr. Carl R. Johnson of the Department of Chemistry at Wayne State University. Professor Johnson will focus his work on the application of enzymes as catalysts in key steps of the synthesis of complex organic molecules.