Development of Chemoenzymatic Approaches to Bioactive Molecules

这项研究的重点是在复杂分子合成的关键步骤中使用酶。这些酶的底物是容易从简单的环碳氢化合物如环戊二烯、苯、环庚三烯、环庚烯和1,5-环庚二烯的氧化中获得的介孔化合物。酶促反应将有助于揭示多个手性中心。由此产生的构建模块将暴露在许多合成方案中，包括使用过渡金属催化的偶联反应，以获得各种生物感兴趣的分子。有了这个基于成就的更新奖，合成有机项目正在支持韦恩州立大学化学系的卡尔·r·约翰逊博士的研究。约翰逊教授将把他的工作重点放在酶作为催化剂在复杂有机分子合成关键步骤中的应用上。

The focus of this research is the use of enzymes in key steps of the synthesis of complex molecules. The proposed substrates for the enzymes are meso compounds readily available from the oxidation of simple cyclic hydrocarbons such as cyclopentadiene, benzene, cycloheptatriene, cycloheptene and 1,5-cyclooctadiene. The enzymatic reactions will serve to unveil multiple chiral centers. The resulting building blocks will be exposed to a number of synthetic protocols,including the use of transition metal-catalyzed coupling reactions, to give various classes of molecules of biological interest. %%% With this Accomplishment Based Renewal award, the Synthetic Organic Program is supporting the research of Dr. Carl R. Johnson of the Department of Chemistry at Wayne State University. Professor Johnson will focus his work on the application of enzymes as catalysts in key steps of the synthesis of complex organic molecules.