2D Biomedical Hyperspectral Imager

描述(由申请人提供)： Kestrel公司的这项提案提供了一种新的三维(两个空间，一个光谱)高光谱成像仪，用于临床和生物医学研究应用。Kestrel的三维高光谱视网膜成像仪概念融合了两项正在开发的技术，傅立叶变换高光谱成像技术和积分场光谱。这两种技术允许在二维区域中对成像区域进行空间采样，同时保留每个样本中的光谱信息。然后对这些样本进行处理和重组，以创建一个完整的三维数据立方体，其中包含具有所选区域的完整光谱内容的两个空间维度。 这项建议的具体目标是： 目的1：开发一种实验室验证原理的三维高光谱医学成像仪，它可以在一次曝光中收集两个空间维度和完整的光谱数据，供体内医学使用。 目标2：收集表征数据，以证明可以收集三维高光谱图像，并显示这些数据比目前可用的数据更有价值。 这项技术的应用广泛存在于生物医学成像领域。高光谱医学成像的价值，特别是其在眼科应用中的应用，正在慢慢得到认可。然而，目前这些高光谱设备的实施限制了它们向广泛的临床和活体研究用途的过渡，因为收集三维数据立方体所使用的技术在实际目的中是不可用的。提出的技术提供了克服这一限制的潜力。最初的目标展示了基本的光学技术和工程，并为解决长期目标奠定了基础，这些长期目标旨在将该技术引入临床研究原型设备，如光学分子成像或内窥镜，并记录三维数据在这些应用中的价值。

DESCRIPTION (provided by applicant): This proposal from the KESTREL CORPORATION offers a new three dimensional (two spatial, one spectral) hyperspectral imager for use in clinical and biomedical research applications. Kestrel's three dimensional hyperspectral retinal imager concepts merge two developing technologies, Fourier Transform hyperspectral imaging technology and integral field spectroscopy. The two technologies allow an imaged region to be spatially sampled in a two dimensional area while retaining the spectral information in each sample. These samples are then processed and reassembled to create a full three dimensional data cube containing two spatial dimensions with full spectral content of the selected area. The Specific Aims of this proposal are: Aim 1: Development of a laboratory proof of principle three-dimensional hyperspectral medical imager that collects two spatial dimensions and a full compliment of spectral data in a single exposure for medical in vivo use. Aim 2: Collection of characterization data to demonstrate that three dimensional hyperspectral images can be collected and to show the increased value of these data over what is available today. Applications for this technology exist across a wide range of biomedical imaging. The value of hyperspectral medical imaging and especially its application in ocular uses is slowly gaining recognition. However, the current implementation of these hyperspectral devices limits their transition to wide spread clinical and research in vivo uses because of the techniques employed in collecting a three dimensional data cube are for practical purposes unusable. The technology proposed offers the potential of overcoming this limitation. The initial objectives demonstrate the underlying optica technologies and engineering, and set the stage for addressing long term objectives that will be directed at introducing the technology into clinical research prototype devices, such as an optical molecular imaging or an endoscope, and documenting the value of three dimensional data in these applications.