Magnetic Encoded Sortable Particle Arrays

描述(申请人提供)：该项目的目标是开发一种基于编码可分选粒子(ESP)技术的新型‘液体阵列’平台。ESP是一种光学编码的微细加工颗粒，可以使用磁力进行操纵。它们是在商业上可用的光刻设备上制造的，使用从半导体行业借来的高效和坚固的技术。与现有的珠基液体阵列平台相比，它们在成本、吞吐量、可扩展性和灵活性方面具有显著优势。我们将开发一种液体阵列系统，可以容纳1000多路或更多的多路复用级别，并且将比现有系统更灵活、更易于使用。它的设计还将允许大幅降低资本和运行成本，以及类似或更好的定量性能，包括精密度、检测极限和动态范围。 电除尘技术将为多种不同类型的分析提供广阔的平台。它本质上是多才多艺的，有潜力用于基础生物医学研究，以及高通量发现和临床诊断。能够对颗粒进行磁性控制是一个显著的优势。这项技术有潜力用于癌症和其他多种疾病的基础研究、诊断和预后。

DESCRIPTION (provided by applicant): The aim of this project is to develop a novel 'liquid array' platform, based on Encoded Sortable Particle (ESP) technology. ESPs are optically-encoded microfabricated particles that can be manipulated using magnetic force. They are manufactured on commercially available photolithographic equipment, using efficient and robust techniques borrowed from the semiconductor industry. They have significant advantages in cost, throughput, scalability, and flexibility over existing bead-based liquid array platforms. We will develop a liquid array system that can accommodate multiplexing levels of 1,000-plex or more, and that will be more flexible and easier to use than existing systems. Its design will also permit substantially lower capital and running costs and similar or better quantitative performance, including precision, limit of detection and dynamic range. The ESP technology will provide a broad platform for many different kinds of assays. It is intrinsically versatile, and has the potential to be used in basic biomedical research, as well as high-throughput discovery and clinical diagnostics. The ability to control the particles magnetically is a significant advantage. The technology has the potential to be useful in basic research, diagnosis and prognosis of cancer, and a wide variety of other diseases.