Minority Predoctoral Fellowship Program

描述（由申请人提供）：本提案描述了一个为期5年的培训计划，以完成斯坦福大学免疫学研究生课程。主要研究者是一名医学博士/博士生，他已经完成了医学院的前两年，并开始了他的研究生学习。斯坦福大学结合了基础科学和临床研究的优势，特别是因为它涉及免疫学的分子基础，因此将是我在学术医学领域发展职业生涯的肥沃环境。 我的建议集中在巨噬细胞激活的分子方面，特别是因为它涉及到核激素受体，过氧化物酶体增殖物激活物受体γ和δ的信号。以前的研究已经确定这些转录因子作为巨噬细胞脂质代谢，炎症反应和动脉粥样硬化的关键调节因子。然而，这些受体控制巨噬细胞生物学和活化的分子程序仍然知之甚少。本拨款申请中提出的研究将采用生物化学，分子和遗传学方法进一步研究PPAR γ和δ如何协调巨噬细胞对脂肪酸的反应。

DESCRIPTION (provided by applicant): This proposal describes a 5-year training program for completing the graduate program in Immunology at Stanford University. The principal investigator is an MD/PhD student, who has completed the first two years of medical school and is beginning his graduate studies. Stanford University combines strengths in both basic science and clinical research, especially as it pertains to the molecular basis of immunology, and thus will be fertile environment for developing my career in academic medicine. My proposal focuses on molecular aspects of macrophage activation, especially as it relates to signaling by nuclear hormone receptors, PPAR gamma and delta. Previous studies by various laboratories have identified these transcription factors as key regulators of macrophage lipid metabolism, inflammatory response and atherosclerosis. However, the molecular programs by which these receptors control macrophage biology and activation remain poorly understood. The studies proposed in the present grant application will take biochemical, molecular, and genetic approaches to further investigate how PPAR gamma and delta orchestrate the macrophage response to incoming fatty acids.