How chronic stress and depression harm the heart

人们对抑郁症损害心脏的机制知之甚少。这是特别令人不安的，因为最近的证据表明，虽然抗抑郁药减轻了抑郁症患者的负面情绪，但它们并没有消除对心脏的危险。我们将使用动物模型来确定：抑郁症如何影响心脏的电稳定性;所涉及的大脑机制的身份;以及哪些药物可以用来保护心脏免受抑郁症的有害影响。

Very little is known about mechanisms whereby depression harms the heart. This is especially disturbing as recent evidence indicates that while antidepressants alleviate a depressed persons negative mood, they do not eliminate danger to the heart. We will use an animal model to determine: How depression affects the electrical stability of the heart; The identity of the brain mechanisms that are involved; and which drugs can be used to protect the heart fro the harmful effects of depression.