Collaborative Urological Research in Spinal Cord Injury

描述(申请人提供)：泌尿系统并发症是 脊髓损伤患者最常见和最具破坏性的健康问题。然而这件事 这一重要领域还没有得到显著的研究重视。特别是 缺乏泌尿科医生、康复物理学家和基础医生之间的合作 科学家。SCI(Curp-SCI)中的泌尿外科协作研究项目 匹兹堡大学成立于1998年，旨在巩固 在众多对脊髓损伤神经生理学感兴趣的实验室中， 细胞生物学、组织力学和先进治疗学。的目标是 Curp-SCI将通过以下方式促进协作、跨学科研究计划 目的是开发合理的治疗脊髓泌尿系功能障碍的方法。那里 方案中有四个项目和三个核心：项目1。 脊髓损伤后逼尿肌反射亢进的发展(William de Groat，药理学)； 项目2.脊髓损伤后膀胱力学的改变(Michael Sack， 生物力学)；项目3.脊髓损伤患者膀胱癌的生物标记物 (Robert Getzenberg，泌尿学和匹兹堡癌症研究所)；和项目4。 神经源性膀胱的新干预策略(迈克尔·舒尔， 泌尿科)。核心是：A.行政核心(迈克尔·财政大臣)；B. 患者和组织银行核心(Rajiv Dhir)；和C.SCI Animal Core(William De Groat)。尽管所有四个项目都将进行动物研究，但也有 重点关注脊髓损伤患者的临床相关性和护理改进。 项目4(大法官博士)将连接一项关于膀胱内香草素的研究 树脂毒素膀胱内注射的动物模型及同期临床试验 (RTX)在神经原性膀胱患者。项目2和3也将有直接的 与人膀胱组织和尿液分析的临床相关性(CORE B)。 该计划与地区性SCI和MS计划相结合 超过250万人。约翰·霍顿博士，康复部 医学，是脊髓损伤临床项目的主任。黛安·博雷洛-法国， 理疗和康复医学系博士，威尔 监督和指导临床结果和数据分析。该计划建立在 参与者对SCI研究的承诺以及协同和 实验室的合作历史。它利用了 相当大的大学资源，将在更多的地方开展 超过25,000 S.F.设备齐全的实验室和临床空间。本计划 对于促进病人护理和基本了解 脊髓损伤与神经源性膀胱功能障碍。

DESCRIPTION (provided by applicant): Urological complications are one of the most common and devastating health problems for SCI patients. Yet this important field has not received significant research attention. Especially lacking is collaboration among urologists, rehabilitation physicists and basic scientists. The Collaborative Urologic Research Program in SCI (CURP-SCI) at the University of Pittsburgh was organized in 1998 to build upon the strengths of the large number of laboratories interested in SCI neurophysiology, cellular biology, tissue mechanics and advanced therapeutics. The goal of the CURP-SCI is to foster collaborative, interdisciplinary research programs with the aim of developing a rational therapy for SCI urologic dysfunction. There are four Projects and three Cores in the Program: Project 1. Mechanisms of detrusor hyperreflexia development after SCI (William de Groat, Pharmacology); Project 2. Alterations in bladder mechanics in SCI (Michael Sacks, Biomechanics); Project 3. Biomarkers of bladder cancer in SCI individuals (Robert Getzenberg, Urology and Pittsburgh Cancer Institute); and Project 4. Novel intervention strategies for neurogenic bladder (Michael Chancellor, Urology). The Cores are: A. Administrative Core (Michael Chancellor); B. Patient and Tissue Banking Core (Rajiv Dhir); and C. SCI Animal Core (William de Groat). Although all four projects will have animal studies, there is also focus on clinical correlation and improvement of care for SCI patients. Project 4 (Dr. Chancellor) will bridge a study of intravesical vanilloids in animal models and concurrent clinical trial of intravesical resiniferatoxin (RTX) in neurogenic bladder patients. Projects 2 and 3 will also have direct clinical correlation with analysis of human bladder tissue and urine (Core B). The program is integrated with the regional SCI and MS programs that serve over 2.5 million people. Dr. John Horton, Department of Rehabilitation Medicine, is the Director of the SCI Clinical Program. Diane Borello-France, Ph.D., Department of Physical Therapy and Rehabilitation Medicine, will oversee and direct clinical outcome and data analysis. This Program builds on the commitment of the participants to SCI research and the synergistic and collaborative history of the laboratories. It takes advantage of the considerable resources of the university and will be carried out in the more than 25,000 s.f. of fully equipped laboratory and clinical space. This Program is important for the advancement of patient care and basic understanding of SCI and neurogenic bladder dysfunction.