The development of synthetic cells using industry 4.0 technologies

化学生物学和合成细胞科学领域提供了从非生命成分构建仿生实体的潜力，合理组合以创建可定制的结构元件和功能途径。这些结构通常以“人造细胞”的形式出现，旨在维持复杂的生命反应，包括新陈代谢、交流、决策、运动甚至进化，并有望彻底改变基础科学和应用科学。该研究将着眼于新一代合成细胞的开发，该细胞具有在作用部位靶向递送和合成的能力。再加上物理科学的创新，它们的设计和建造将通过与增材制造、人工智能（AI）和机器学习（ML）等工业4.0平台的集成来驱动，从而实现设计测试周期的数字化。这将促进参数的高通量扫描，例如膜底盘组成，其进而调节合成细胞稳定性、经由生物电路的信号传播速率和细胞-环境通信。将3D微流体打印与机器人技术和自动化技术相结合，改变合成细胞构建领域。

Chemical biology and the field of synthetic cell science offer the potential to construct biomimetic entities from non-living components, rationally combined to create tailorable structural elements and functional pathways. These constructs, often taking the form of 'artificial cells', are designed to sustain complex life-like responses, including metabolism, communication, decision making, motility, and even evolution, and promise to revolutionise fundamental and applied science. This studentship will look at the development of a new generation of synthetic cells with the capability for targetted delivery and synthesis at the site of action. Coupled with innovation in the physical sciences their design and construction will be driven through integration with industry 4.0 platforms such as additive manufacturing, artificial intelligence (AI) and machine learning (ML), leading to digitisation of the design-test cycles. This will facilitate the high-throughput sweeping of parameters such as membrane chassis composition which in turn regulate synthetic cell stability, the rate of signal propagation via bio-circuitry and cell-environment communication. Coupling 3D microfluidic printing with robotics and automation with transform the field of synthetic cell construction.