A Novel Post-Menopausal Osteoporosis Screening Tool

描述（由申请人提供）： 骨质疏松症对美国人口有重大影响，超过2500万人受到这种疾病的影响。通常情况下，这种易患的退行性疾病每年导致约130万例骨折，成本超过100亿美元。这项修订后的拨款申请将开发和评估一种新的，但经济的技术，这有可能被用作一个非侵入性和客观的工具，用于检测绝经后骨质疏松症妇女脊柱骨折的迹象。所提出的非侵入性技术可以提供有关骨质量的关键信息，可以补充传统的DEXA骨矿物质密度（BMD）测量。绝经后骨质疏松症技术将利用微型皮肤安装式加速度计来捕获与足跟撞击诱导力传播相关的人体肌肉骨骼系统（软组织，包括肌肉和在健康骨骼中具有显著弹性能力的骨小梁）的天然减震器的有效阻尼能力和其他机械性能（包括脆性）的变化。 文献缺乏关于骨质疏松症如何影响天然减震器的信息。由于我们小组的初步研究已经成功地定量了另一种类型的退行性肌肉骨骼疾病（即骨关节炎患者）中肌肉骨骼系统的天然减震器，因此所提出的技术捕获骨质疏松性骨骼减震特性的能力的成功潜力很高。 所提出的技术是完全非侵入性的，客观的，简单和快速的管理。拟议的研究将侧重于测量绝经后骨质疏松症与骨折和补充信息收集的BMD测量的自然减震性能。一旦提出的技术显示出前景，未来的前瞻性研究将允许确定该技术的有效性，以诊断个人的骨折风险，临床前。

DESCRIPTION (provided by applicant): Osteoporosis has a significant impact on the United States population, with more than 25 million people affected by the disease. Often times, this predisposed degenerative disease leads to about 1.3 million fractures per year with the costs being in excess of 10 billion dollars. This revised grant application will develop and evaluate a novel and yet economical technique, which has the potential to be used as a non-invasive and objective tool for detecting indications of spine fractures in post-menopausal osteoporotic women. The proposed non-invasive technique can provide critical information about the quality of the bone that can supplement traditional DEXA bone mineral density (BMD) measurements. The post-menopausal osteoporosis technique will utilize miniature skin mounted accelerometers to capture the changes in effective damping capacities and other mechanical properties (including brittleness) of natural shock absorbers of the human musculoskeletal systems (soft tissues including muscles and trabecular bone which has significant elastic capacity in healthy bones), associated with heel strike induced force propagation. The literature lacks information regarding how osteoporosis affects natural shock absorbers. The potential of success for the proposed technique's ability to capture shock absorption properties of osteoporotic bones is high since preliminary studies from our group have successfully quantitated natural shock absorbers of the musculoskeletal system in another type of degenerative musculoskeletal diseases i.e. osteoarthritic patients. The proposed technique is totally non-invasive, objective, simple and quick to administer. The proposed study will focus on measuring natural shock absorption properties of postmenopausal osteoporosis with and without fractures and supplement information gathered from BMD measurements. Once the proposed technique shows promise future prospective study will allow determination of the effectiveness of the technique to diagnose individuals at risk for fracture, pre-clinically.