Biosensing platforms to detect bacterial lectins

该项目将为与疾病相关的蛋白质产生新的生物传感器。我们将设计和合成一个类似于哺乳动物细胞表面的共聚物库，并有望与细菌细胞和病毒表面表达的碳水化合物结合蛋白相互作用。这些材料将被探索为新的诊断设备的基础，以快速诊断感染，基于包括荧光在内的敏感检测策略，以及包括热传递方法和热波传输分析在内的无标记策略。

This project will generate new biosensors for proteins associated with disease. We will design and synthesise a library of copolymers which resemble the mammalian cellular surface, and are expected to interact with carbohydrate-binding proteins expressed on the surfaces of bacterial cells and viruses. These materials will be explored as the basis for new diagnostic devices to rapidly diagnose infection, based on sensitive detection strategies including fluorescence, and label-free strategies including the heat transfer method and thermal wave transport analysis.