Mouse Models of Endometriosis and Ovarian Cancer

描述（由申请人提供）：上皮性卵巢癌是女性生殖道最致命的癌症。目前，既没有可靠的早期检测手段，也没有非常有效的治疗方案。在散发性和家族性卵巢癌发生中起主要病因作用的遗传性病变包括激活性K-RAS突变（K-RASG 12 D）和功能丧失性p53、PTEN和BRCA 1突变。这个建议的主要目标是描述我最近开发的子宫内膜异位症和卵巢癌小鼠模型的特征。 这些研究将使我能够评估子宫内膜异位症和卵巢癌之间的发病联系。此外，对这些模型的分析将使新的治疗靶点的鉴定成为可能。最后，它们将允许在相关的体内环境中筛选未来的治疗剂和化学预防剂。

DESCRIPTION (provided by applicant): Epithelial ovarian cancer is the deadliest cancer of the female reproductive tract. Currently, there is neither a reliable means for early detection nor very efficient treatment options. Genetic lesions that have a major etiological role in sporadic and familial ovarian carcinogenesis include activating K-RAS mutations (K-RASG12D) and loss-of-function p53, PTEN, and BRCA1 mutations. The main goal of this proposal is to characterize the mouse models of endometriosis and endometrioid ovarian cancer that I recently developed. These studies will allow me to evaluate the pathogenetic links between endometriosis and endometrioid ovarian cancer. Furthermore, the analysis of these models will make possible the identification of new therapeutic targets. Finally, they will allow the screening of future therapeutic and chemopreventive agents in a relevant in vivo context.