The Molecular Basis of Head and Neck Cancer Therapy

描述(申请人提供)：一个综合性的多学科 翻译研究计划的提出将显著改善 头颈部癌减量的诊断、治疗和预防 与这种疾病相关的发病率和死亡率。这一点的重点是 卓越研究专业计划(孢子)是对 创新的器官保存治疗方法将减少患者 制定、测试和纳入健全的预防战略 采用系统性治疗方法，解决远处转移和 第二原发癌。五个拟议项目和三个发展项目 项目将探索化疗和放射治疗的分子基础。 治疗决定(项目1、2、5)和远处转移的风险 (项目3、4、5)或肿瘤复发/第二原发癌(项目3)。 这种孢子的总体假设是，未来治疗的进展 头颈部癌症的预防将建立在更好的理解基础上 个体特有的特定分子和基因改变 肿瘤。基于这一假设，更具体和更少病态的治疗 将开发和测试优化器官保存的养生法， 播散性疾病复发的预防和治疗。高度重视 在这个孢子是放在职业发展和先导研究项目 发展以确保持续创新和新产品数量的增加 研究人员致力于头部和颈部的翻译研究。一个有限的 还提出了关键基础设施核心的数量。这个头 而颈孢子是密歇根大学的一个完全集成的组成部分 综合癌症中心。我们建议广泛使用癌症中心核心 设施、临床和实验室资源和研究人员，以及 严重依赖有经验的癌症中心领导层。经验丰富的优秀团队 临床/基础合作伙伴结合了高度的机构承诺和 优先，和广泛的患者资源提供了出色的研究 确保成功实现孢子总目标的环境。

DESCRIPTION (provided by applicant): A comprehensive multidisciplinary translational research program is proposed that will significantly improve the diagnosis, treatment and prevention of head and neck cancer while decreasing morbidity and mortality associated with this disease. The emphasis in this Specialized Program of Research Excellence (SPORE) is the development of innovative organ preservation treatment approaches that will reduce patient morbidity and to develop, test and incorporate sound prevention strategies with systemic treatment approaches that will address distant metastases and second primary cancers. Five proposed projects and three developmental projects will explore the molecular basis for chemotherapy and radiation treatment decisions (Projects 1, 2, 5) and the risk of distant metastases (Projects 3, 4, 5) or tumor recurrence/second primary cancer (Project 3). The overall hypothesis of this SPORE is that future advances in the treatment and prevention of head and neck cancer will be based on better understanding of specific molecular and genetic alterations characteristic of individual tumors. Based on this hypothesis, more specific and less morbid treatment regimens will be developed and tested that optimize organ preservation, prevention of recurrence and therapy of disseminated disease. Strong emphasis in this SPORE is placed on career development and pilot research project development to ensure ongoing innovation and increases in the numbers of new investigators dedicated to head and neck translational research. A limited number of critical infrastructure cores are also proposed. This Head and Neck SPORE is a fully integrated component of the University of Michigan Comprehensive Cancer Center. We propose extensive use of Cancer Center core facilities, clinical and laboratory resources and investigators, and draw heavily on experienced Cancer Center leadership. Superb teams of experienced clinical/basic collaborators combined with high institutional commitment and priority, and extensive patient resources provide an outstanding research environment that will ensure success in achieving overall SPORE goals.