Ventilator-Associated Pneumonia. Bactericidal Trachea

1.我们之前已经开发了一种方法，通过使用导管头端安装的可膨胀球囊完全清洁插管绵羊的气管插管管腔，球囊配有两个“刮除环”;在扩张和取出粘液刮除器时，气管插管内的所有粘液都在一次清扫中被清除。 2.目前正在进行后期测试/评估的是一种新型系统，该系统在实施时能够保持气管导管和气管无粘液，并且无细菌定植;不需要气管或气管导管抽吸。 3.基于上述研究和我们的先前研究，将由前客座研究员（Dr. Lorenzo贝拉）与PCCM合作开展一项临床研究，以评价1.粘液刮刀和2.在聚氨酯中涂有磺胺嘧啶银的气管插管。该临床方案已获得意大利参与医院管理部门的IRB和NHLBI IRB的批准。患者人群包括内科ICU中的患者和心脏外科患者

1. We have previously developed a method to totally clean the lumen of the tracheal tube in intubated sheep thorough the use of a catheter tip mounted inflatable balloon, provided with two "Shaving Rings"; upon inflation and retrieval of the Mucus Shaver, all mucus within the tracheal tube is removed in one sweep. 2. Now undergoing late stage test/evaluation is a novel system that, when implemented, is capable to maintain the tracheal tube, and the trachea free of mucus, and free of bacterial colonization; with no need for tracheal, or tracheal tube suctioning. 3. Based on above studies, and our preceeding studies, a clinical study is to be conducted headed by a former Visiting Fellow (Dr. Lorenzo Berra), in collaboration with PCCM, to evaluate clinical benefits of 1.The mucus shaver and 2. Tracheal tubes coated with silver sulfadiazine in polyhurethane. Such clinical protocol has been approved by the IRB of the participating hospital administration in Italy, and by the NHLBI IRB. The patient population is to consist of both patients in the medical ICU; and cardiosurgical patients