ADD As Assessed By Event Related Brain Potentials

我们在《生物心理学》上发表了一篇关于季节对认知ERP（事件相关脑电位）成分振幅影响的报告（Kosmidis et al., 1999）。在准备期间，有关于可乐定（一种去甲肾上腺素阻滞剂）对正常受试者erp影响的报告，以及正常对照和两组癫痫患者之间的比较。后一项研究表明，颞叶癫痫患者的erp在大多数方面与正常对照者相似；与此相反，缺失性癫痫患者的erp表现为认知成分的波幅降低，尤其是P300和慢波。这种差异主要体现在听觉信号的处理上。我们希望与健康科学统一服务大学的同事们一起重新启动这个项目。一篇描述闭合性头部损伤对注意力要求任务中erp影响的手稿发表在《心理生理学》杂志上。研究结果表明，与刺激识别和分类有关的N200成分的变化在这些患者中发生了改变，特别是在听觉模式中。这些可能是信息处理的永久性变化，因为这些患者在受伤后平均7年。客座研究员邓肯博士和我也提出了一项关于这一领域的综述，该综述将发表在《国际心理生理学杂志》上

We have published in Biological Psychology a report of seasonal effects on the amplitude of cognitive ERP (Event-Related brain Potentials) components (Kosmidis et al., 1999). In preparation at this time are reports of the effects of clonidine (a norepinephrine blocker) on ERPs in normal subjects, as well as a comparison among normal controls and two groups of patients with seizure disorders. The latter study indicated that ERPs in patients with temporal lobe seizures resemble in most respects those seen in normal control subjects; in contrast, ERPs in patients with absence epilepsy show reduced amplitudes of cognitive components, especially P300 and slow wave. The differences were seen primarily in the processing of auditory signals. We are hoping to reactivate this project, in conjunction with colleagues at the Uniformed Services University of the Health Sciences. A manuscript describing the effects of closed head injuries on ERPs in attention-demanding tasks has been published by the journal Psychophysiology. The findings indicate that changes in the N200 component, concerned with identification and classification of stimuli, is altered in these patients, particularly in the auditory modality. These are presumably permanent changes in information processing, as the patients were on the average seven years post-injury. Dr. Duncan, a Guest Researcher, and I have also proposed a review of this general area, which is to appear in the International Journal of Psychophysiology