Overcoming transport barriers for multistage delivery of extracellular vesicles in oncology

该项目由工程和物理科学研究理事会(EPSRC)赞助，旨在开发治疗妇科癌症的新型仿生药物输送方法。使用多尺度仓库方法，这些先进的给药方法将能够优先在转移部位蓄积，并保持治疗有效载荷的生物活性。多阶段多孔颗粒(MSV)将用于纳米颗粒和细胞毒性药物的局部输送，以调节靶细胞功能并重新连接恶性过程。

Sponsored by the Engineering and Physical Sciences Research Council (EPSRC), the project aims to develop novel biomimetic drug-delivery approaches for gynaecological cancers. Using multi-scale depot approaches, these advanced delivery methods will be able to preferentially accumulate at metastatic sites and maintain the bioactivity of therapeutic payloads. Multistage porous particles (MSV) will be used for localized delivery of nanoparticles and cytotoxic drugs, to modulate target cell function and rewire malignant processes.