Neuroimaging Research Center: High Field Facility

描述（由申请人提供）：本提案是对NCRR RFA RR-03-009的回应，旨在申请资金分摊购买3.0特斯拉先进一代大口径磁共振成像（MRI）扫描仪的成本，以支持达特茅斯医学院、达特茅斯希区柯克医学中心（DHMC）和塞耶工程学院的多个人类和动物健康相关研究项目。一个校园范围内的多学科研究人员联盟，每年超过1500万美元的成像相关赞助研究迫切需要获得最先进的高场扫描能力，以实现当前和新兴的科学目标。一项详细的技术研究检查了研究者在场强、梯度和射频线圈平行成像、软件集成和其他功能方面所需的关键功能。拟议的NRC的代表性主要用户群包括：（1）衰老和阿尔茨海默病;（2）焦虑症治疗;（3）生物信息学和图像分析;（4）生物物理学、生物工程学和放射学研究计划;（5）脑损伤研究计划：人类和动物模型;（6）心血管成像和血管生成中心;（7）认知神经科学计划;（8）癫痫和功能性神经外科;（9）多发性硬化中心;（10）神经肿瘤学、放射和化疗成像研究;（11）儿科精神药理学;（12）精神分裂症、情感障碍和物质滥用研究;（13）脊柱和肌肉骨骼临床研究中心;（14）其他用户、试点项目和培训赠款/奖学金计划。NRC将由一个经验丰富的团队广泛使用和管理。它将变得自给自足，并大大提高许多领先的研究人员的科学生产力。它还将促进未来生物医学科学家的培训。

DESCRIPTION (provided by applicant): This proposal, in response to the NCRR RFA RR-03-009, requests funds to cost share the purchase of a 3.0 Tesla advanced generation large bore magnetic resonance imaging (MRI) scanner to support multiple programs of human and animal health-related research at Dartmouth Medical School and College, Dartmouth Hitchcock Medical Center (DHMC) and the Thayer School of Engineering. A campus wide multidisciplinary consortium of investigators with over $15M in annual imaging related sponsored research urgently requires access to state of the art high field scanning capability to accomplish current and emerging scientific goals. A detailed technical study examined the critical features needed by investigators in terms of field strength, gradients, and radiofrequency coils parallel imaging, software integration and other features. Representative Major User Groups for the proposed NRC include: (1) Aging and Alzheimer's Disease; (2) Anxiety Disorders Treatment; (3) Bioinformatics and Image Analysis; (4) Biophysics, Bioengineering and Radiological Research Programs; (5) Brain Injury Research Programs: Human and Animal Models; (6) Cardiovascular Imaging and Angiogenesis Centers; (7) Cognitive Neuroscience Program; (8) Epilepsy and Functional Neurosurgery; (9) Multiple Sclerosis Center; (10) Neuro-Oncology, Radiation and Chemotherapy Imaging Studies; (11) Pediatric Psychopharmacology; (12) Schizophrenia, Affective Disorders and Substance Abuse Research; (13) Spine and Musculoskeletal Clinical Research Centers; (14) Other Users, Pilot Projects and Training Grants/Fellowship Programs. The NRC will be extensively utilized and administered by an experienced team. It will become self-sufficient and greatly enhance the scientific productivity of many leading investigators. It will also facilitate the training of future biomedical scientists.