Magnetic Hydrogels for Bone Tissue Engineering

组织工程学用于在事故、手术切除或功能丧失后，为因疾病而受损或需要替换的组织产生基于实验室的替代。其策略是开发在生物和机械特性方面模仿自然组织的3D结构，然后允许细胞生长、发育和分化为功能组织。在这方面，水凝胶作为3D模型已经有了既定的记录。由于创伤、肿瘤切除、疾病(如骨质疏松症)或骨骼异常对组织替代的需求增加，骨组织工程备受瞩目。工程化的3D骨材料可以利用不同的刺激，加速组织的修复和再生。特别是，磁刺激可以促进更多的骨形成，允许更快和更好的愈合过程。静磁场可以促进骨髓间充质干细胞(MSCs)的增殖、迁移和成骨细胞的分化，并诱导其成骨。在本课题中，我们的目标是制备用于骨组织工程的磁性水凝胶，并将其与静磁场相结合，促进骨髓MSCs的成骨。

Tissue engineering is used to generate lab-based replacements for tissues which have been damaged or need replacement due to disease, following an accident, surgical excision or loss of function. The strategy is to develop 3D structures which mimic the natural tissue in terms of the biological and mechanical properties, this then allows for cell growth, development and differentiation into functional tissue. In this regard, hydrogels have an established track record as 3D models.Bone tissue engineering is high profile due to the increased need for tissue replacement in trauma, tumour excision, disease (e.g. osteoporosis) or skeletal abnormalities. Engineered 3D materials for bone can make use of different stimuli, to accelerate the repair and regeneration of the tissue. In particular, magnetic stimulation can promote increased bone formation, allowing for a more rapid and better healing process. Static magnetic fields were found to accelerate cell proliferation, migration and the differentiation of osteoblast-like cells, as well as induce osteogenesis in bone marrow-derived mesenchymal stem cells (MSCs).In this project, we aim to generate magnetic hydrogels for bone tissue engineering, which in combination with a static magnetic field, will act to accelerate osteogenesis in bone marrow MSCs.