SPORE in Skin Cancer

在本提案中，我们寻求在哈佛大学和布里格姆妇女医院新配置的达纳法伯哈佛癌症中心内建立一个皮肤癌卓越研究专业计划（SPORE）。达纳-法伯哈佛癌症中心SPORE包括来自哈佛医学院和公共卫生学院的研究人员，以及布里格姆妇女医院、贝斯以色列女执事医疗中心、儿童医院医疗中心、达纳-法伯癌症研究所和马萨诸塞州总医院的研究人员。这些机构围绕黑色素瘤和皮肤肿瘤学的转化研究主题走到一起，提出了五个项目，五个共享资源（核心），一个发展计划和一个癌症发展计划。项目1将把流行病学发现转化为改进的黑色素瘤风险模型的开发;一旦开发出来，这些模型将在大量患者人群中得到验证。项目2采用全基因组转录谱的力量，最终目标是提高我们诊断和预测原发性黑色素瘤生物学过程的能力。项目3测试假设，皮肤T细胞淋巴瘤是一个恶性的记忆T细胞，通常执行皮肤的免疫监视的人口，并寻求确定新的治疗目标。项目4和5是令人兴奋的转化临床试验。在项目4中，使用新的免疫学终点直接比较了两种完全不同的树突状细胞疫苗接种策略。在项目5中，采用生物化学治疗方法来治疗转移性黑素瘤。将再次进行免疫学监测，目的是改善黑色素瘤患者的治疗。这五个项目由五个核心组成。生物统计学核心为每项研究提供专家咨询，而组织和病理学核心为这些项目提供受控和有组织的组织访问。免疫学终点评估。临床数据管理核心提供了创建动态和灵活的数据库的重要服务，这些数据库集成了多个哈佛附属医院的项目。最后，一个发展计划的特点是五个项目，其中每一个都是一个候选人演变成一个完整的项目是有前途的翻译结果。一个职业发展计划，它需要在职业生涯的医生科学家的发展的广泛观点，是这个应用程序的核心。一个行政结构已经到位，将确保监督，整合，规划，教学活动，最重要的是，如果获得有希望的翻译结果，将发展和演变成一个完整的项目。一个职业发展计划，它需要在职业生涯的医生科学家的发展的广泛观点，是这个应用程序的核心。一个行政结构已经到位，将确保监督，整合，规划，教学活动，最重要的是，未来五年的增长和发展的孢子。

In this proposal, we seek to establish a Specialized Program of Research Excellence (SPORE) in Skin Cancer at Harvard University and Brigham and Women's Hospital, within the newly configured Dana Farber Harvard Cancer Center. The Dana-Farber Harvard Cancer Center SPORE includes investigators from Harvard Medical School and School of Public Health, as well as the Brigham and Women's Hospital, Beth Israel Deaconess Medical Center, Children's Hospital Medical Center, Dana- Farber Cancer Institute, and the Massachusetts General Hospital. These institutions have come together around the theme of translational research in melanoma and cutaneous oncology Five Projects, five Shared Resources (Cores), a Developmental Program, and a Cancer Development Program are proposed. Project 1 will translate epidemiologic findings into the Development of improved risk models for melanoma; once developed, these will be validated across a large patient population. Project 2 employs the power of whole genome transcriptional profiling with the ultimate goal of improving our ability to diagnose and predict the biological course of primary melanoma. Project 3 tests the hypothesis that cutaneous T cell lymphoma is a malignancy of a population of memory T cells that normally performs immunosurveillance of the skin, and seeks to identify new targets for therapy. Projects 4 and 5 are exciting translational clinical trials. In Project 4, two diametrically different dendritic cell vaccination strategies are directly compared, using novel immunological endpoints.. In Project 5, biochemotherapeutic approaches are employed to treat metastatic melanoma. Immunologic monitoring will be performed again with the goal of improving therapy for melanoma patients. These five Projects are integrated by five Cores. The Biostatistics Core provides expert consultation to each study while the Tissue and Pathology Core provides controlled and organized access to tissue vital for these projects. An assessment of immunologic endpoints. The Clinical Data Management Core provides a vital service of creating dynamic and flexible databases that integrate Projects across multiple Harvard-affiliated hospitals. Finally, a Development Program features five projects, each of which is a candidate for evolution into a full project is promising translational results are obtained. A Career Development Program, which takes a broad view of the development of the physician scientist over the course of a career, is a centerpiece of this application. An administrative structure is in place that will assure oversight, integration, planning, didactic activities, and most importantly, the growth and evolution into a full project if promising translational results are obtained. A Career Development Program, which takes a broad view of the development of the physician scientist over the course of a career, is a centerpiece of this application. An administrative structure is in place that will assure oversight, integration, planning, didactic activities, and most importantly, the growth and evolution of the SPORE over the next five years.