Harvard Skin Disease Research Center

描述（由申请人提供）：哈佛皮肤病研究核心中心（HSDRC）资助了哈佛大学及其附属医院近15年的核心服务和试点和可行性研究。我们中心的倡议帮助建立了一个充满活力的科学家社区（研究基地），他们对皮肤相关的生物医学研究产生了重大影响。目前的研究基地成员中有近一半是新加入的。我们的核心设施为不熟悉皮肤病或不熟悉皮肤病模型的科学家提供了方便的途径，使他们能够获得高度专业化的服务和资源。在过去十年中，我们的损益项目计划资助了46项创新提案。总体而言，HSDRC的资助已导致数百篇论文发表，并使NIH和其他来源的许多新的校外资助成为可能。我们估计，从P&F研究的后续资金来看，单是P&F项目就产生了20倍的“投资回报”。在本提案中，提出了四个服务核心设施。细胞培养中心将为HSDRC社区提供广泛的服务和独特的细胞/细胞系，并将引入诱导多能干细胞（IPS）方法。形态学和细胞分析核心将提供高度专业化和独特的一般和分子病理学服务。转基因和小鼠模型核心将提供最先进的方法来产生与皮肤研究相关的转基因小鼠。白细胞迁移核心将为研究免疫和干细胞迁移的生物学和生物物理学提供独特的服务。提出了四项高度创新的P&F研究，每项研究都至少使用了一个核心的服务。最后，提出了两个试点核心，全部由机构资金支持。转化研究资源核心旨在促进使用临床材料和人类受试者的皮肤病研究，化学生物学核心将使用新的高通量方法筛选与皮肤病相关的化合物。行政核心由相当多的机构支持，确保核心和P&F研究在运营、预算和资源方面得到成功管理。我们相信，HSDRC将继续对皮肤病研究产生重大影响。

DESCRIPTION (provided by applicant): The Harvard Skin Disease Research Core Center (HSDRC) grant has funded Core services and Pilot and Feasibility Studies throughout Harvard and its affiliated hospitals for nearly 15 years. Our Center's initiatives have helped build a vibrant community of scientists (Research Base) who have made a major impact on biomedical research relevant to skin. Nearly half of the current Research Base members are new additions. Our Core facilities have provided scientists unfamiliar with skin diseases, or skin as a model of disease, with easy access to highly specialized services and resources. Our P&F Project Program has funded 46 innovative proposals over the past ten years. In aggregate, HSDRC funding has led to hundreds of published papers and has enabled many new extramural grants from the NIH as well as other sources. We estimate that the P&F Program alone has yielded a >20-fold "return on investment", as judged by subsequent funding that resulted from the P&F studies. In the present proposal, four service Core facilities are proposed. The Cell Culture Core will provide a broad range of services and unique cells/cell lines to the HSDRC community, and will introduce inducible pluripotent stem cell (IPS) approaches. The Morphology and Cell Analysis Core will provide highly specialized and unique general and molecular pathology services. The Transgenic and Mouse Models Core will provide state-of-the-art approaches to the generation of transgenic mice relevant to the study of skin. The Leukocyte Migration Core will provide unique services to study the biology and biophysics of immune and stem cell migration. Four highly innovative P&F studies are proposed, each of which uses services from at least one of the Cores. Finally, two pilot Cores are proposed, which are supported entirely by institutional funds. A Translational Research Resources Core is designed to facilitate skin disease research using clinical materials and on human subjects, and a Chemical Biology Core will use new and high throughput approaches to screen compounds relevant to skin disease. An Administrative Core, bolstered by considerable institutional support, ensures that the Cores and P&F studies are managed successfully with regard to operations, budget, and resources. We are confidant that the HSDRC will continue to make a major impact on skin diseases research.