ALZHEIMER'S DISEASE RESEARCH CENTER

描述(由申请人提供)：过去的四年是阿兹海默症研究中心(ADRC)在UAB发展壮大的时期。这份申请书代表着将我们的ADRC再延续五年的请求。这个ADRC由5个核心和3个小项目组成。行政核心将执行ADRC的所有目标，包括预算、执行委员会和内部和外部咨询委员会的会议，通过试点赠款(即为AD研究引入新的调查人员)、每月一系列研讨会以及与其他阿尔茨海默病中心的互动来提高知名度。临床核心中心将继续跟踪以前招募的患者，每年招募30名对照组、30名轻度认知障碍(MCI)、30名轻度AD和30名帕金森病痴呆症(PDD)患者。每年将进行神经心理评估和安排尸检。数据管理和生物统计核心将提供统计咨询、数据管理，并将所有需要的信息发送给国家反腐败委员会。神经病理学核心将提供诊断、处理和存储组织(脑、脑脊液)的新技术，并将这些技术提供给UAB和其他机构的研究人员。教育和信息传输核心将为医生、辅助专业人员和非专业人士社区(重点是非裔美国人)提供教育，维护演讲者局，照顾者时事通讯，有关AD的信息包，继续我们的年度继续医学教育课程，与罗伊巴尔中心一起完成的其他课程，维护我们的网页，并通过多媒体传播ADRC的研究。通过研究AD、PDD和MCI患者以及照顾者的行为、纵向和功能变化，这三个项目被主题联系在一起。其中一个项目将检查MCI患者与正常老年人相比的功能(例如驾驶)变化。第二个项目将审查AD、PDD和控制方面的医疗决策能力的丧失。第三个项目将确定对照顾者的干预是否会在他们的“所爱的人”发展到中度/重度AD时改善照顾者的适应能力。行政当局在哲学和财政上大力支持亚洲发展研究中心，支付行政长官的工资，并为亚洲发展研究中心翻新多个区域。在UAB继续建立ADRC将使我们能够继续AD的临床和基础研究工作，并将使我们能够扩展到新的研究领域(例如PDD、MCI)。

DESCRIPTION (provided by applicant): The past four years have been a time of development and growth of the Alzheimer's Disease Research Center (ADRC) at UAB. This application represents a request to continue our ADRC for an additional five years. This ADRC is composed of 5 Cores and 3 small projects. The Administrative Core will provide the implementation of all goals of the ADRC including budgets, meetings of the Executive and Internal and External Advisory Committees, enhancing visibility through pilot grants (i.e. bring new investigators to AD research), a monthly seminar series and interactions with other Alzheimer's Disease Centers. The Clinical Core will continue to follow previously recruited patients and recruit 30 controls, 30 mild cognitive impairment (MCI), 30 mild AD, and 30 Parkinson's Disease with dementia (PDD) patients annually. Annual neuropsychological assessments and arrangement for autopsy will be performed. The Data Management and Biostatistics Core will provide statistical consultation, data management and send all required information to the NACC. The Neuropathology Core will provide new techniques for diagnosis, process and store tissue (brain, CSF) and make these available to investigators at UAB and other institutions. The Education and Information Transfer Core will provide education to physicians, paraprofessionals and lay communities (with emphasis on African-Americans), maintain a Speakers Bureau, caregivers' newsletters, packets of information on AD, continue our annual CME courses with every other one done in conjunction with the Roybal Center, maintain our web page and disseminate ADRC research through multimedia. The 3 Projects are thematically linked by studying behavioral, longitudinal and functional change in AD, PDD and MCI patients and in caregivers. One Project will examine functional (e.g. driving) change in MCI patients as compared to normal older adults. A Second Project will examine the loss of medical decision making capacity in AD, PDD and controls. A Third Project will determine if interventions with caregivers while their "loved one" still has mild AD will improve caregivers' adjustment when their "loved one" progresses to moderate/severe AD. The Administration strongly supports the ADRC both philosophically and financially, paying the salary of the Administrator as well as renovating multiply areas for the ADRC. Continuation of an ADRC at UAB would allow us to continue both clinical and basic research efforts in AD and would allow us to expand into new research areas (e.g. PDD, MCI).