Core Facilities for Neurobiology at Brandeis

描述（由申请人提供）：我们申请资金建立三个核心设施，以支持10个nind资助的布兰代斯大学研究项目（研究者：Rosbash， Birren, Griffith, Hall, Lisman, Marder, Sengupta, Turrigiano, Welte, White）。提出了三个新设施：一个微阵列/FACS设施，一个转基因小鼠设施和一个集成的多仪器成像设施。要求为每个设施的设备、人员和用品提供资金。每个设施都将有一个监督委员会，每个监督委员会的主席，Sengupta, Birren， Turrigiano和Rosbash将组成指导委员会，监督整个设施的管理。这组由NINDS资助的研究人员在突触传递神经调节机制，早期神经发育和突触形成，行为遗传学和神经元功能的分子底物方面有着共同的兴趣。拟议的新设施不会复制布兰迪斯大学校园内的任何现有设施，并且对于我们使用最新的最先进的方法进行我们资助的研究至关重要，这些方法现在已成为我们领域的标准。这些设施还将加强布兰迪斯大学其他NIH资助的研究人员的研究。布兰迪斯大学通过提供资金翻新空间和设备，对这些新设施作出了重大承诺。

DESCRIPTION (provided by applicant): We request funds to establish three core facilities to support 10 NINDS-funded research projects (investigators: Rosbash, Birren, Griffith, Hall, Lisman, Marder, Sengupta, Turrigiano, Welte, White) at Brandeis University. Three new facilities are proposed: A microarray/FACS facility, a transgenic mouse facility, and an integrated, multi-instrument imaging facility. Funds are requested for equipment, personnel, and supplies for each of the facilities. Each facility will have an oversight committee, and the chair of each of these oversight committees, Sengupta, Birren, and Turrigiano together with Rosbash, will constitute the Steering Committee to oversee the administration of the entire facility. This group of NINDS- funded investigators share common interests in the mechanisms of synaptic transmission neural modulation, early neural development and synapse formation, genetics of behavior, and the molecular substrates of neuronal function. The proposed new facilities do not duplicate any existing facilities on the Brandeis University campus and are essential to allow us to conduct our funded research employing the new state of the art methods now becoming standard in our field. These facilities will also enhance research by other NIH funded investigators at Brandeis University. Brandeis University has made a substantial commitment to these new facilities by providing funds for renovation of space and equipment.