Diabetes: Implant Integration, Success, and Benefit

描述（由申请人提供）：糖尿病的一种更微妙的并发症是由于牙齿脱落和功能受损导致患者生活质量下降。虽然种植体治疗在糖尿病患者中显示出良好的前景，但关于这种全身性疾病对牙科种植体治疗的影响仍然存在问题。事实上，通过植入治疗改善饮食控制，可能是那些血糖控制不足的患者获益最多。目的：我们的长期目标是为糖尿病患者的植入护理制定患者特异性治疗方案提供科学依据。本研究旨在解决以下目标：1）确定2型糖尿病和血糖控制对功能负荷前后牙种植体整合，并发症和成功的影响。2)确定2型糖尿病和血糖控制对口腔健康相关生活质量的影响，与下颌全口义齿添加种植体支持相关。研究方法：一项平行设计的前瞻性研究将评估种植体整合、成功、并发症、口腔健康相关的生活质量和无牙颌患者的满意度，以及将义齿转换为双种植体支持的下颌覆盖义齿后1至3.5年。将从控制良好（HbA 1c <8.0%）或控制不良（HbA 1c 8.1-12%）的2型糖尿病患者和非糖尿病健康对照受试者中招募患者（45名受试者/组）。将从圣安东尼奥/南德克萨斯地区招募所有患者（n=135）。这项研究旨在利用糖尿病的高患病率。在这个领域。成果：评估包括种植体失败（移除或未修复）、临床并发症、作为种植体整合指标的共振频率分析（RFA）、口腔健康相关生活质量、满意度和饮食。含义：该提案通过检查血糖控制和种植体治疗之间的特定关系，对现有的关于对缺乏良好血糖控制的糖尿病患者使用种植体治疗的范例提出了挑战。它探讨了植入治疗为血糖控制较差的糖尿病患者提供重要的功能、营养和生活质量益处的潜力。最终，这些信息将有助于建立以证据为基础的指南，用于糖尿病患者牙种植治疗的评估和应用。

DESCRIPTION (provided by applicant): One of the more subtle complications of diabetes mellitus is a decrease in the patient's quality of life due to tooth loss and compromised function. While implant therapy has shown promise in patients with well- managed diabetes, questions remain as to the influence of this systemic condition on dental implant therapy. In fact, it may be those patients with inadequate glycemic control that have the most to gain by improvements in dietary control through implant therapy. Purpose: Our long-term goal is to develop the scientific rationale for the development of patient-specific, therapeutic protocols for implant care in diabetic patients. This study seeks to address the following aims: 1) Determine the impact of type 2 diabetes and glycemic control on dental implant integration, complications, and success both before and after functional loading. 2) Identify the impact of type 2 diabetes and glycemic control on oral health-related quality of life associated with the addition of implant-support to mandibular complete dentures. Methods: A parallel design, prospective study will assess dental implant integration, success, complications, oral health-related quality of life and satisfaction for edentulous patients with conventional dentures, and through 1 to 3.5 years after converting the denture to a 2-implant supported mandibular overdenture. Patients will be recruited (45 subjects/group) from well-controlled (HbA1c<8.0%) or poorly-controlled (HbA1c 8.1-12%) type 2 diabetic patients, and non-diabetic, healthy control subjects. All patients (n=135) will be recruited from the San Antonio/south Texas area. This study looks to capitalize on the high prevalence of diabetes. in this area. Outcomes: Assessments include implant failures (removal or non-restored), clinical complications, resonance frequency analysis (RFA) as a measure of implant integration, oral health-related quality of life, satisfaction, and diet. Implications: This proposal challenges existing paradigms regarding the utilization of dental implant therapy for diabetic patients lacking good glycemic control by examining the specific relationship between glycemic control and implant therapy. It explores the potential for implant therapy to provide important functional, nutritional, and quality of life benefits to diabetes patients with poorer glycemic control. Ultimately, this information will contribute to the establishment of evidence-based guidelines for the assessment and application of dental implant therapy for patients with diabetes.