Mapping the dynamics and regulation of the skin cell cytoskeleton during ageing

细胞骨架的变化与皮肤成纤维细胞老化和对化学和机械应力的反应有关。在这个多学科的项目中，我们将使用最先进的生物成像技术，包括超分辨率显微镜和定制的分析工具，来定义衰老过程中成纤维细胞骨架的时空组织和动态。我们将通过生物图像信息学生成与年龄相关的网络签名，以获得可以用各种化合物进行研究的早期衰老图。的博士候选人将接受先进的成像技术，先进的显微镜图像计算分析，细胞培养方法和最新的蛋白质组学技术的培训。该项目源于达勒姆大学的细胞生物学家和纽卡斯尔大学的数据科学家之间的合作，共同致力于在生物科学领域取得新的发现。该项目还与我们的国际工业合作伙伴宝洁公司合作，宝洁公司将在美国宝洁中心实验室实习期间提供培训。

Cytoskeletal changes are associated with skin fibroblast ageing and responses to chemical and mechanical stress. In this multi-disciplinary project, we will use state-of-the-art bioimaging technologies, including super-resolution microscopy and bespoke analytical tools, to define the spatial and temporal organisation and dynamics of the fibroblast cytoskeleton during ageing. We will generate age-related network signatures through bioimage informatics to obtain maps for early ageing that can be investigated with various compounds. The Ph.D. candidate will receive training in advanced imaging techniques, advanced computational analysis of microscope images, cell culture methods and the latest proteomic technologies. The project stems from a collaboration between cell biologists at Durham University and data scientists at Newcastle University, working together to deliver novel discoveries in the Biosciences. The project is also in collaboration with our international industrial partner Procter & Gamble, who will provide training during a placement at the P&G central labs in the USA.