The comorbidity of obsessive-compulsive disorder and schizophrenia: the interplay between psychosocial and genetic risk.

强迫症（OCD）和精神分裂症（SCZ）是高度共病的两种精神疾病，但二者共病的机制尚不清楚。本研究利用雅芳亲子纵向研究（Avon Longitudinal Study of Parents and Children，ALSPAC）的纵向队列研究和英国生物样本库的数据，1）通过网络模型研究强迫症和SCZ之间的症状水平关联，并确定有助于解释这两种疾病共同发生的桥梁症状; 2）确定强迫症和SCZ的共同和非共同的心理社会危险因素;（3）通过多基因风险评分评估强迫症与SCZ共病的基因-环境相互作用。

Obsessive-compulsive disorder (OCD) and schizophrenia(SCZ) are highly comorbid; however, the mechanismsunderlying this comorbidity are not well researched. Usingdata from Avon Longitudinal Study of Parents and Children(ALSPAC) longitudinal cohort study and the UK Biobank, Iwill 1) investigate symptom level associations betweenOCD and SCZ using network modelling and identify thebridge symptoms that can help explain the co-occurrenceof these two disorders; 2) identify common and uniquepsychosocial risk factors underlying OCD and SCZ; 3)examine polygenic risk scores to assess gene-environmentinterplay underlying the comorbidity between OCD andSCZ.