Neural and behavioral trajectories of the overcontrolled phenotype: Associations with development, social context and psychiatric symptoms in early childhood

过度控制表型的神经和行为轨迹：与幼儿期发育、社会背景和精神症状的关联

• 批准号: 10443029
• 负责人: Kirsten Gilbert
• 金额: $ 69.15万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-01 至 2027-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10443029
• 关键词: 6 year old; 9 year old; Adolescence; Adult; Age; Anorexia Nervosa; Attenuated; Behavioral; Behavioral Mechanisms; Child; Child Rearing; Childhood; Chronic; Cognitive; Communities; Crystallization; Data; Development; Dimensions; Disease; Early Intervention; Early identification; Electroencephalogram; Evaluation; Event-Related Potentials; Exhibits; Frequencies; Functional disorder; Goals; Grain; Impairment; Intervention; Investigation; Knowledge; Longevity; Mental disorders; Mentored Patient-Oriented Research Career Development Award; Methods; Monitor; Neurobiology; Neuronal Plasticity; Obsessive-Compulsive Disorder; Onset of illness; Outcome; Performance; Phenotype; Process; Psychopathology; Public Health; Research; Research Domain Criteria; Resistance; Risk; Sampling; School-Age Population; Schools; Severities; Social Anxiety Disorder; Social Development; Social Environment; Social Processes; Symptoms; Techniques; Time; aged; cognitive control; cognitive development; cognitive process; comorbidity; contextual factors; control theory; cost effective; design; early childhood; experience; high risk; improved; indexing; insight; neurobiological mechanism; neurodevelopment; novel; peer; psychiatric symptom; recruit; relating to nervous system; response; severe psychiatric disorder; social; social influence

PROJECT SUMMARY Heightened performance monitoring and overcontrol (HPM/OC) is a transdiagnostic phenotype comprised of perfectionism, extreme concern for errors, cognitive inflexibility and excessive need for control. There is increasing evidence that the HPM/OC phenotype is identifiable in early childhood and underlies obsessive- compulsive disorder (OCD), social anxiety disorder (SAD) and anorexia nervosa (AN). These psychiatric disorders are severe, chronic, and treatment-resistant disorders with high rates of comorbidity. However, there is surprisingly little research examining the neurobiological and behavioral mechanisms that make up the HPM/OC phenotype in early school-age childhood in relation to the development of transdiagnostic psychiatric symptoms. Moreover, it is unknown how the HPM/OC phenotype interacts with rapid developmental progression during this age or is influenced by social-contextual features, such as social evaluation, peer rejection or parenting styles. Determining answers to these fundamental questions could provide insight into the emergence of the HPM/OC phenotype and provide novel treatment targets for early intervention. The goal of the current proposal is to improve understanding of the HPM/OC phenotype in early childhood in relation to early markers of OCD and SAD by assessing the developmental progression of cognitive facets of performance monitoring and reactive versus proactive cognitive control and the influence of social-contextual features on psychiatric outcomes. We posit that cognitive processes that make up the HPM/OC phenotype, including heightened performance monitoring and more reactive versus proactive cognitive control, interact with various social contexts to differentiate early school-age children with impairing HPM/OC. The early school- age period is when HPM/OC is first evident and is a time of rapid cognitive and social development, making it a pivotal time to understand the developmental psychopathology of this presentation. We will employ cutting- edge and cost-effective electroencephalogram (EEG) event-related potential (ERP) and time-frequency (TF) analyses to examine multiple Research Domain Criteria (RDoC) constructs across three repeated yearly assessments in a sample of 300 community children oversampled for elevated dimensional HPM/OC, ages spanning 4 - 9 years. This fine-grained evaluation will provide an opportunity to characterize 1) how HPM/OC impacts normative neurodevelopmental trajectories of RDoC constructs during an age of high neural plasticity, 2) the developmental progression of cognitive facets of the HPM/OC phenotype in relation to transdiagnostic psychiatric impairment and 3) the impact of social-contextual features that may influence these relationships. This knowledge could have far-reaching effects on our understanding of the early neurodevelopment of the HPM/OC phenotype prior to disorder onset, which could inform early identification of high-risk children and targeted early interventions that could lessen the severity, course and impairment of multiple psychiatric disorders across the lifespan.

项目总结 增强型性能监控和过度控制(HPM/OC)是一种跨诊断表型，包括 完美主义、对错误的极端关注、认知上的僵化和对控制的过度需求。的确有 越来越多的证据表明，HPM/OC表型在儿童早期就可以识别出来，并成为强迫症的基础。 强迫症(OCD)、社交焦虑症(SAD)和神经性厌食症(AN)。这些精神病患者 疾病是严重的、慢性的、难治性疾病，具有很高的共患率。然而，在那里 令人惊讶的是，几乎没有研究来检验构成 学龄儿童HPM/OC表型与跨诊断精神病学发展的关系 症状。此外，HPM/OC表型如何与快速发育相互作用尚不清楚 在这个年龄段的进步或受社会背景特征的影响，如社会评价、同伴 拒绝或养育方式。确定这些基本问题的答案可以提供对 HPM/OC表型的出现，为早期干预提供了新的治疗靶点。目标是 目前的建议是提高对儿童早期HPM/OC表型与以下方面的理解 强迫症和自闭症的早期标志物评估认知方面的发展 绩效监控、反应性认知控制与主动性认知控制以及社会语境的影响 关于精神结果的特写。我们假设构成HPM/OC表型的认知过程， 包括更高的性能监控和更具反应性的主动认知控制、交互 通过不同的社会背景来区分患有HPM/OC受损的早期学龄儿童。早期的学校- 年龄段是HPM/OC首次出现的时期，是认知和社会快速发展的时期，使其成为 这是理解这一陈述的发展精神病理学的关键时刻。我们将使用切割- 边缘和经济实惠的脑电(EEG)事件相关电位(ERP)和时频(Tf) 分析以检查三年重复的多个研究领域标准(RDoC)结构 对300名年龄段HPM/OC升高的社区儿童进行过度抽样的评估 时间跨度为4-9年。这一精细的评估将提供一个机会来描述1)HPM/OC 在神经可塑性很高的时代影响RDoC结构的标准神经发育轨迹， 2)HPM/OC表型认知方面的发展与跨诊断的关系 精神障碍和3)可能影响这些关系的社会背景特征的影响。 这一知识可能会对我们理解儿童早期神经发育产生深远的影响。 疾病发作前的HPM/OC表型，这可能有助于早期识别高危儿童和 有针对性的早期干预，可以减轻多发性精神病患者的严重程度、病程和损害 一生中都会出现疾病。