Core--Bioinformatics

生物信息学核心（BC）的目标是提供网络可访问的注释，编目设施和最先进的生物信息学分析。这将使所有三个项目的研究人员能够最大限度地利用基因表达，多态性和蛋白质组学数据集来确定已知基因和表达序列标签（EST）之间的功能依赖关系，并指导这些推定依赖关系的进一步生物学验证（表达载体核心解决了这一关键的生物学验证步骤）。BC将使用人类和小鼠表达序列的Affymetrix基因芯片阵列将项目三中原位杂交研究的数据连接到微阵列中心。它还将整合来自项目的蛋白质组数据和基因型数据。

The goal of the Bioinformatics Core (BC) will be to provide web-accessible annotation, cataloging facilities and state-of-the-art bioinformatics analyses. This will enable researchers from all three of the projects to maximally utilize the gene expression, polymorphism and proteomic data sets to determine functional dependencies among the known genes and Expressed Sequence Tags (ESTs) and direct further biological validation of these putative dependencies (the expression vector core addresses this critical biological validation step). The BC will connect data from in situ hybridization studies in project three to microarray centers using Affymetrix GeneChip arrays of human and murine expressed sequences. It will also integrate proteomic data and genotype data from the projects.