Core--Outcome Measures and Cell Preparation

核心B提供用于治疗的细胞以及方案项目所有组成项目的基本结果衡量标准。神经功能和行为是项目1(骨髓间充质干细胞治疗中风)和项目2(骨髓间充质干细胞治疗创伤性脑损伤)的主要结果指标，并被广泛应用于项目3(骨髓间充质干细胞与组织相互作用的分析)。在这个核心中，我们描述了用于评估对MSC治疗的反应的功能测试集。测试包括运动和躯体感觉测试，以及神经学评分。项目1-3还涉及注射的MSCs的命运，这些细胞产生的因素及其对促进改善功能结果的脑组织的影响，以及MSCs对内源性实质细胞的影响。这个核心提供了细胞鉴定、营养因子的测量和鉴定以及显微镜所需的所有资源。这三个项目都使用了骨髓基质细胞。核心B提供专门用于生产和表征这些电池的设施和人员。集中核心B中各组成部分项目所需的资源，可以有效和有效地利用所有三个项目所必需的资源。

Core B provides the cells to be employed for treatment as well as the essential outcome measurements for all constituent projects of the Program Project. Neurologic function and behavior are the primary outcome measures for Project 1 (Treatment of Stroke with MSCs) Project 2 (Treatment of Traumatic Brain Injury with MSCs) and are extensively employed in Project 3 (Analysis of MSC Interaction with Tissue). In this core, we describe the sets of functional tests to be employed in evaluating response to MSC therapy. Included in the battery of tests are, motor and somatosensory tests, and neurological scales. Projects 1-3 also address the fate of the injected MSCs, the factors produced by these cells and their effect on cerebral tissue that promote improved functional outcome, and the effects of MSCs on the endogenous parenchymal cells. This core provides all the resources required for cellular identification, measurement and identification of trophic factors, and microscopy. All three projects employ marrow stromal cells. Core B, provides the facilities and personnel dedicated to the production and characterization of these cells. Focusing resources needed for the component projects in Core B, allows for efficient and effective utilization of resources essential for all three projects.