Enhancing Translational Biomedical Research in Alaska.

描述(由申请者提供)：阿拉斯加土著健康研究中心(CANHR)与阿拉斯加西南部农村的尤皮克·爱斯基摩人社区合作开展健康差距研究。阿拉斯加费尔班克斯大学(UAF)代表CANHR和专门的神经科学研究计划(ABNP)提议翻新费尔班克斯北极健康研究大楼(AHRB)的空置空间，以增加3600平方英尺的生物医学研究空间，并在阿拉斯加州贝瑟尔的库斯科维姆校区增加约1400平方英尺的空间。伯特利是56个尤皮克人爱斯基摩人村庄的中心城市，我们在这些村庄进行健康差距研究。伯特利的Kuskokwim校区靠近育空-Kuskokwim卫生公司大楼和医院。我们有机会扩展我们的物理基础设施，并共同配置我们在生物医学研究方面的智力资源，以在UAF科学家与爱斯基摩农村尤皮克社区进行翻译研究(T1-T4)和在UAF校园进行基本发现工作台研究(T1)之间创造协同效应。空间的增加将积极影响我们在UAF进行更多面向临床的研究的能力，并定期与我们工作了八年的地区的阿拉斯加原住民农村研究合作伙伴和参与者进行沟通。这将显著增加该州和全国经济最贫困的少数族裔社区之一的就业机会。我们提议的研究的具体目标是：具体目标1：翻新费尔班克斯园区北极健康研究大楼(AHRB)1566英尺2的计划空间，创建一个综合的临床和营养评估套件，旨在研究了解和消除爱斯基摩人之间的健康差距。具体目标2：建立一个1899 net ft2程序空间的电生理学实验室，利用动物模型进行实验，旨在了解婴儿猝死综合征(SID)的病因和尼古丁对大脑的影响。具体目标3：翻新我们在伯特利分校的一个空地，以建造一个与AHRB翻新平行的设施。它将增加参与者的参与度，创造就业机会，并在育空库什科维姆(YK)地区建设研究能力。这一设施将允许我们的研究人员在YK工作时在临床研究设施中面对面地收集数据。意义：这个翻新的设施将增加对肥胖和慢性病以及在服务不足的社区中其他健康差距的研究。它将加强沟通，传播研究成果，从专家组到社区的翻译，并改进数据收集。

DESCRIPTION (provided by applicant): The Center for Alaska Native Health Research (CANHR) conducts health disparities research in partnership with Yup'ik Eskimo communities in rural Southwest Alaska. The University of Alaska Fairbanks (UAF), on behalf of CANHR and the Specialized Neuroscience Research Program (ABNP), proposes to renovate empty space in the Arctic Health Research Building (AHRB) in Fairbanks to add 3600 ft2 of space devoted to biomedical research, and another ~1400 ft2 on the Kuskokwim campus in Bethel, Alaska. Bethel is the hub city for the 56 Yup'ik Eskimo villages in which we conduct health disparities research. The Kuskokwim campus in Bethel is in close proximity to the Yukon-Kuskokwim Health Corporation building and hospital. The opportunity exists to expand our physical infrastructure and co-locate our intellectual resources in biomedical research to create a synergy between UAF scientists conducting translational research with rural Yup'ik Eskimo communities (T1-T4), and basic discovery bench research (T1) on the UAF campus. The increased space will positively impact our ability to conduct more clinically-oriented research at UAF and communicate regularly with our rural Alaska Native research partners and participants in the region in which we have worked for eight years. It will significantly increase jobs in one of the most economically depressed minority communities in the state and nation. The specific aims of our proposed research are: Specific Aim 1: To renovate a net of 1566 ft2 of program space in the Arctic Health Research Building (AHRB) on the Fairbanks campus to create an integrated clinical and nutritional assessment suite directed at research on understanding and eliminating health disparities among Yup'ik Eskimos. Specific Aim 2: To build an electrophysiology lab of 1899 net ft2 of program space to conduct experiments using animal models aimed at understanding the etiology of Sudden Infant Death Syndrome (SIDS) and the effects of nicotine on the brain. Specific Aim 3: To renovate an empty space at our branch campus in Bethel to build a facility that parallels the AHRB renovation. It will increase participant engagement, create jobs and build research capacity in the Yukon Kuskokwim (YK) region. This facility will allow our researchers to collect data face-to-face in a clinical research facility when working in the YK. Significance: This renovated facility will increase research on obesity and chronic diseases and other health disparities among an underserved community. It will enhance communication, dissemination of research results, translation from bench to community and improve data collection.