Construction of (A)BSL-3 Laboratory of Infectious Diseases at the University of S

描述(由申请人提供)：这是一个建造一个新的，独立的25,800平方英尺的建议书。美国南阿拉巴马大学传染病实验室(LID)大楼，将容纳新的BSL-2、BSL-3和动物BSL-3(ABSL-3)实验室。需要新的空间来维持和支持现有的、成熟的和备受推崇的研究计划，并为专注于对人类健康和安全构成重大威胁的精选病原体的扩大计划提供空间。拟议的设施将在功能上取代目前的BSL-3实验室大楼--分子生物学实验室(LMB)。LMB成立于1978年，拥有微生物学和免疫学系的研究人员，他们对立克次体属的人类精选制剂病原体进行资金充足的研究项目，最近已扩大到包括伯克霍尔德氏菌精选制剂病原体。拟议的设施将解决与LMB有关的两个问题。首先，它将为研究人员提供单独的BSL-2和BSL-3实验室区域，通过允许使用适当的方案进行较低的封闭性研究，同时单独保持BSL-3级别研究所需的较高封闭性条件，大大简化和加快研究速度。其次，它将通过提供动物BSL-3(ABSL-3)实验室向大学研究界提供关键的新资源，这些实验室对于评估宿主与病原体的相互作用、测试与致病机制相关的假说以及开发新的治疗方法和疫苗至关重要。该设施的建设将对美国的生物医学研究产生积极影响，增强研究竞争力，并获得支持美国就业的资金。该盖子将通过支持短期工程和建筑工作以及包括教师、研究技术人员和学生在内的长期研究职位来刺激南阿拉巴马州地区的经济。

DESCRIPTION (provided by applicant): This is a proposal to construct a new, stand-alone 25,800 sqft. Laboratory of Infectious Diseases (LID) building at the University of South Alabama (USA) that will house new BSL-2, BSL-3, and animal BSL-3 (ABSL-3) laboratories. New space is needed to sustain and support existing, well-established, and highly-regarded research programs as well as to provide space for an expanding program focused on Select Agent pathogens that pose significant threats to human health and security. The proposed facility will functionally replace the current BSL-3 laboratory building, the Laboratory of Molecular Biology (LMB). The LMB, established in 1978, houses investigators of the Department of Microbiology and Immunology who conduct well-funded research programs on human Select Agent pathogens of the genus Rickettsia and has recently expanded to include Burkholderia Select Agent pathogens. The proposed facility will address two problems associated with the LMB. Firstly, it will provide separate BSL-2 and BSL-3 laboratory areas for the investigators, greatly simplifying and accelerating the pace of research by allowing lower containment studies to be conducted using appropriate protocols while separately maintaining the higher containment conditions required for BSL-3 level studies. Secondly, it will provide a critical new resource to the university research community by providing animal BSL-3 (ABSL-3) laboratories which are essential for evaluating host-pathogen interactions and for testing hypotheses related to pathogenic mechanisms and for the development of new therapies and vaccines. The construction of the facility will positively impact biomedical research at USA, strengthening research competitiveness and the acquisition of funds to support American jobs. The LID will stimulate the economy of the South Alabama region by supporting both short-term engineering and construction jobs as well as long term research positions including faculty, research technologists and students.