Kidneys Fail:Translating basic mechanisms into therapies

描述(由申请人提供)： 本申请申请资助高级博士后研究员和初级教员参加“肾脏衰竭：将疾病进展的基本机制转化为新疗法”会议的旅行奖励。会议将于2005年11月8日至9日在宾夕法尼亚州费城的宾夕法尼亚会议中心举行，作为2005年美国肾脏学会(ASN)肾周的一部分。 虽然纤维化是肾脏和慢性进行性疾病领域的一个重要话题，但在过去的几年里，它一直是令人惊讶的很少有会议的主题。已经取得了重大进展，现在是时候审查在肾脏研究之外取得的进展，并向致力于这一问题不同方面的社区成员介绍已经获得的见解。因此，该计划将包括来自其他领域的研究人员和那些寻求肾脏新方法的人。此外，会议的一个组成部分将把翻译和临床研究人员聚集在一起，以确定在确定进展标志方面取得了哪些进展，并将这些进展与新的基本机制联系起来。鉴于目前的学术界环境，研究人员往往很难出席多个会议；与ASN年度会议一起举行这一深入会议将为与进展性肾脏疾病相关领域工作的其他人提供机会，使他们能够在不增加第二次旅行的情况下享受这次会议和ASN会议的好处。 课程分为4个部分：(1)器官纤维化的非肾脏模型，(2)基质重塑的分子机制，(3)细胞损伤和恢复的机制，(4)发展进行性肾脏疾病的新疗法。 该计划包括两次招待会和一次普通午餐，以及咖啡休息时间，以鼓励受邀演讲者和与会者之间的互动。我们过去的经验是，这些更多的社交活动是鼓励肾脏和非肾脏社区内部和之间合作的重要组成部分。

DESCRIPTION (provided by applicant): The present application requests funds to support travel awards for senior postdoctoral fellows and junior faculty to attend the conference, "Why Kidneys Fail: Translating Basic Mechanisms of Disease Progression into Novel Therapies." The conference will be held November 8-9, 2005, at the Pennsylvania Convention Center in Philadelphia, PA, as part of the annual American Society of Nephrology (ASN) Renal Week 2005. Although fibrosis is a topic of significant interest in renal and chronic progressive disease fields, it has been the subject of surprisingly few meetings over the past few years. Major advances have occurred, and it would be timely to examine the progress that has been made outside of kidney research, as well as to introduce members of the community who are working on different aspects of this problem to the insights that have been obtained. Thus, the program will include investigators from other areas and those pursuing novel approaches in the kidney. In addition, a component of the meeting will bring translational and clinical investigators together to determine what progress has been made in identifying markers of progression, relating these to new basic mechanisms. Given the current milieu of academia, it is often difficult for investigators to attend multiple meetings; holding this in-depth meeting in conjunction with the annual ASN meeting will offer the opportunity for others working in areas related to progressive kidney disease to enjoy the benefits of both this conference and the ASN meeting without adding a second trip. The program is divided into 4 sessions: (1) Non-renal models of organ fibrosis, (2) Molecular mechanisms of matrix remodeling, (3) Mechanisms of cell injury and recovery, and (4) Developing new therapeutics for progressive renal disease. The program includes two receptions and a common lunch, along with coffee breaks, to encourage interaction among the invited speakers and meeting participants. Our past experience is that these more social events are an important part of encouraging collaboration within and between the renal and non-renal communities.