DIABETES RESEARCH: FROM CELL BIOLOGY TO CELL THERAPY

描述(由申请人提供)： 每年，希望之城国家医学中心的糖尿病、内分泌学和新陈代谢部门都会举办一年一度的糖尿病研讨会，题为“糖尿病研究进展：从细胞生物学到细胞疗法”，以纪念已故的科学家拉赫迈尔·莱文，他负责澄清胰岛素作用的性质。2005年的莱文研讨会将提供前沿的演讲，回顾最新的研究观察，并提供对这一重要领域未来研究方向的洞察。该计划预计将涵盖以下主题：糖尿病和肥胖的遗传学；体重的中央和外围控制；治疗肥胖症的新策略；葡萄糖毒性和脂肪毒性、氧化应激和炎症、糖尿病的继发并发症、住院患者的强化血糖控制、老龄和糖尿病、妊娠和儿童糖尿病、体内和体外胰岛再生和扩张、作为胰岛来源的胚胎和成人干细胞分化、糖尿病的基因治疗、胰岛移植的免疫耐受、胰岛包囊的新进展、超越埃德蒙顿协议时代的胰岛移植、糖尿病的胰腺和肾脏移植，以及胰岛素输送闭环系统的开发。前几年，Levine研讨会吸引了多达400名与会者，但由于以往研讨会的积极反应，今年的计划预计将吸引更多的与会者。2005年Rachmiel Levine研讨会将于2005年11月9日至12日在加利福尼亚州环球城的喜来登环球酒店举行。除了涵盖广泛的糖尿病相关主题外，该计划还将包括年轻研究人员的口头陈述、海报会议和新的小组讨论。Rachmiel Levine科学成就奖将颁发给顶尖的年轻研究人员，以鼓励他们的职业发展。会议预计将吸引来自不同背景的与会者，包括来自美国和国外的知名内分泌学家、糖尿病专家、胰岛生物学家、干细胞和基因转移科学家、移植外科医生、年轻研究人员和管理糖尿病患者的卫生保健专业人员。提交这份申请是为了为2005年Rachmiel Levine糖尿病研讨会申请教育资金，以帮助支持一批年轻研究人员的出席并促进他们的学术生涯发展。资金将用于减少实习生和研究员的注册费用，并用于支付前12名出席会议的青年科学家的旅费和奖项。

DESCRIPTION (provided by applicant): Each year, the Department of Diabetes, Endocrinology and Metabolism at City of Hope National Medical Center holds an annual diabetes symposium entitled, "Advances in Diabetes Research: From Cell Biology to Cell Therapy," in the memory of the late Rachmiel Levine, the scientist responsible for clarifying the nature of insulin action. The 2005 Levine Symposium will provide cutting-edge presentations, review the latest research observations, and provide insight into future research directions in this important field. The program is expected to cover the following topics: genetics of diabetes and obesity, central and peripheral control of body weight, new strategies for the treatment of obesity, glucose toxicity and lipotoxicity, oxidative stress and inflammation, secondary complications of diabetes, intensive glycemic control in the hospitalized patient, aging and diabetes, pregnancy and childhood diabetes, in vivo and ex vivo islet regeneration and expansion, embryonic and adult stem cell differentiation as a source for islets, gene therapy for diabetes, immune tolerance for islet transplantation, new advances in islet encapsulation, islet transplantation beyond the Edmonton Protocol era, pancreas and kidney transplantation for diabetes, and development of closed loop systems for insulin delivery. In prior years, the Levine Symposium has attracted up to 400 attendees, however due to the positive response from prior symposia, this year's program is expected to attract a larger number of attendees. The 2005 Rachmiel Levine Symposium will be held on November 9-12, 2005 at the Sheraton Universal Hotel in Universal City, CA. In addition to covering a wide range of diabetes-related topics, the program will also feature oral presentations from young investigators, poster sessions and new panel discussions. A Rachmiel Levine Scientific Achievement award will be made available to the top presenting young investigators to encourage their career growth. The meeting is expected to attract participants from diverse backgrounds, including well established, endocrinologists, diabetologists, islet biologists, stem cell and gene transfer scientists, transplant surgeons, young investigators, and health care professionals who manage patients with diabetes, from both the U.S. and abroad. This application is being submitted to request educational funding for the 2005 Rachmiel Levine Symposium in Diabetes to help support the attendance of a group of young investigators and foster the development of their academic careers. Funds will be used to reduce registration costs for trainees and fellows and to cover the cost of travel and awards given to the top 12 presenting young scientists.