Gordon Res. Conf: Signal Transduction Within The Nucleus

描述（由申请人提供）：本申请为将于2005年2月6日至11日在加州布尔顿的兰乔·圣巴巴拉万豪酒店举行的关于细胞核内信号转导的戈登研究会议寻求部分资金。所申请的资金将专门用于支持参加会议并以受邀演讲、简短演讲或海报的形式展示其工作的初级研究人员的会议和差旅费。本次会议的主要目标是提供一种形式来回顾和讨论核信号这一新兴领域的最新研究。这一领域的核心是一个新的概念，即与激动剂诱导的质膜代谢类似，激动剂刺激导致核内外第二信使的产生，从而导致核局部第二信使的产生。调控这些第二信使的产生和代谢的机制，以及它们确切的生理作用，是涉及许多酶和调节分子的复杂图景的一部分。本次会议汇集了各种各样的研究人员专注于了解激动剂诱导的这些成分的调制。一些主要的酶包括磷脂酰肌醇特异性磷脂酶Cs、磷脂酰肌醇3-激酶、磷脂酰胆碱特异性磷脂酶Cs、磷脂酶A2s、脂氧合酶、环氧合酶、鞘磷脂酶和糖基化酶。这些酶调节关键信号分子的水平，如二酰基甘油、磷酸肌醇、D-3膦化磷酸肌苷、花生四烯酸和相关的类二十烷、糖蛋白、糖脂和鞘脂。为了解决重要的生理作用，其他主题将包括核信号通路调控的核事件，如染色质重塑，转录和RNA转运。其他主题侧重于这些途径如何促进疾病进程。所要求的资金对支持这次会议将是非常宝贵的。

DESCRIPTION (provided by applicant): This application seeks partial funding for a new Gordon Research conference on Signal Transduction within the Nucleus to be held February 6-11, 2005 at the Rancho Santa Barbara Marriott, Buellton, California. The funds requested will be used exclusively to support the conference and travel expenses of junior investigators who will be attending the conference and presenting their work as invited presentations, short talks or posters. The broad goal of this conference is to provide a form for review and discussion of recent research on the emerging field of nuclear signaling. This field centers on the novel concept that, similar to the agonist-induced metabolism at the plasma membrane, agonist stimulation leads to the generation of second messengers at and within the nucleus that leads to the production of nuclear localized second messengers. The mechanisms involved in regulating the generation and metabolism of these second messengers, and their precise physiological roles, are part of a complex picture that involves many enzymes and regulatory molecules. This conference brings together a wide variety of investigators focused on understanding the agonist-induced modulation of these components. Some of the principal enzymes include phosphoinositide-specific phospholipase Cs, phosphatidylinositol 3-kinases, phosphatidylcholine-specific phospholipase Cs, phospholipase A2s, lipoxygenases, cyclooxygenases, sphingomyelinases and glycosylating enzymes. These enzymes modulate the levels of key signaling molecules such as diacylglycerol, inositol phosphates, D-3 phosphonylated phosphoinositides, arachidonic acid and related eicosanoid, glycoproteins, glycolipids and sphingolipids. To address important physiological roles, other topics will include nuclear events that are regulated by the nuclear signaling pathways such as chromatin remodeling, transcription and RNA transport. Additional topics focus on how these pathways contribute to disease processes. The requested funds will be invaluable to the support of this conference.