5th International Symposium on Hormonal Carcinogenesis

描述（申请人提供）：第五届激素致癌作用国际研讨会（ISHC）的主要目标是聚集一批不同的研究人员，流行病学家，基础科学家和临床医生，以解决类固醇和肽激素和生长因子在因果关系中的作用，依赖，以及在美国和世界范围内折磨女性和男性的一些最流行的癌症的最终激素抵抗。 该ISHC将强调癌症研究的前沿进展，将类固醇激素与以下方面联系起来：1）干细胞研究，2）有丝分裂激酶的过表达，3）类固醇激素受体在激素依赖性肿瘤向非依赖性肿瘤演变中的意义，4）类固醇受体在来自非激素依赖性组织如肺和结肠的实体瘤中的作用，和5）从这些发现衍生的治疗策略的发展。 这次研讨会的计划是平衡的。 它包括基础科学家主要感兴趣的会议，强调导致肿瘤发生，激素依赖性和独立性的分子事件，以及其他与医生具有良好翻译（临床前）成分的强烈临床相关性。 发言的主要群体包括妇女和代表性不足的少数民族。 第五届ISHC科学计划分为四个领域，与激素致癌和激素癌症相关的具体问题有关。 领域1：与激素性癌症相关的病因学。a）成人乳腺癌和前列腺癌干细胞的细胞起源，第1次会议和第1次最新技术展示。B）乳腺、前列腺、血液恶性肿瘤中的有丝分裂激酶、扩增中心体和基因组不稳定性，第2和第3次最新技术水平报告。c）类固醇受体相互作用，第3次会议。 领域2：激素相关癌症风险因素。d）。乳腺、卵巢、前列腺、结直肠、肺的风险评估、生物标志物和激素受体，第4、7次会议和第2次最新技术水平报告。 领域3：预防和治疗。e）关于乳腺癌、前列腺癌和卵巢癌，第5次会议和第2次最新技术展示。 领域4：激素依赖性和独立性。e）前列腺癌、乳腺癌和子宫癌，第6次会议。 和过去一样，将出版一本关于这些介绍的书。

DESCRIPTION (provided by applicant): The primary goal of the 5th International Symposium on Hormonal Carcinogenesis (ISHC) is to gather a diverse group of research investigators, epidemiologists, basic scientists and clinicians to address the role of steroid and peptide hormones and growth factors in the causation, dependence, and eventual hormonal resistance of some of the most prevalent cancers afflicting women and men in the USA and world-wide. This ISHC will emphasize cutting edge progress in cancer research linking steroid hormones to: 1) Stem cell research, 2) Over-expression of mitotic kinases, 3) Significance of steroid hormone receptors in the evolution of hormone-dependent to -independent tumors, 4) Role of steroid receptors in solid tumors from non-hormone dependent tissues such as lung and colon, and 5) Development of therapeutic strategies derived from these discoveries. The planned program for this Symposium is well balanced. It includes sessions of primary interest to basic scientists that emphasize the molecular events leading to oncogenesis, hormone dependency and independency, and others of strong clinical relevance to physicians with a sound translational (pre-clinical) component. The prominent group of speakers includes women and under-represented minorities. The 5th ISHC scientific program has been divided into four areas linked to specific issues pertinent to hormonal carcinogenesis and hormonal cancers. Area 1: ETIOLOGY IN RELATION TO HORMONAL CANCERS. a) Cellular origin in adult breast and prostate cancer stem cells, Session 1 and 1st State of the Art presentation. b) Mitotic kinases, amplified centrosomes, and genomic instability in breast, prostate, hematologic malignancies, Session 2 and 3rd State of the Art presentation. c) Steroid receptor interactions, Session 3. Area 2: HORMONE-RELATED CANCER RISK FACTORS. d). Risk assessment, biomarkers, and hormone receptors in breast, ovary, prostate, colorectal, lung, Sessions 4, 7, and 2nd State of the Art presentation. Area 3: PREVENTION AND TREATMENT. e) In relation to breast, prostate, and ovarian cancer, Session 5 and 2nd State of the Art presentation. Area 4: Hormone Dependency and Independency. e) In prostate, breast and uterine cancer, Session 6. As in the past, a book will be published of the presentations.