Ephrins and Cancer

描述（由申请人提供）：对肝配蛋白及其配体功能的新认识提高了对发育和癌症生物学的新见解的前景。最近，对于结肠癌、前列腺癌、胃癌、食道癌、肺癌、乳腺癌、神经母细胞瘤、脑肿瘤和黑色素瘤，肝配蛋白畸变被报道，并且与恶性行为的转化或进展相关。生物学和病理学以及分子、遗传学、基因组学和实验药物的不同专业领域被应用于理解肝配蛋白作为正常细胞功能的介质或作为治疗癌症的靶点的作用和效用，这为来自这些不同学科和领域的研究人员的集中协调聚集提出了理由，以共享信息，发展协同合作，并找出差距和桥梁，以加快进展。 一个持续的，多年的，年度会议被认为是一个最佳的战略，通过它影响建立更广泛的连接，更全面的赞赏该领域的不同方面，并证明提高生产力的生物学，病理学和药理学ephrins。年度“肝配蛋白与癌症”会议的目的是：1）举办一次多学科会议，使肝配蛋白生物学的主要思想家集中在一起，了解科学的最新情况; 2）针对战略受邀者，填补与癌症过程有关的肝配蛋白生物学方面的“空白”; 3）通过曝光，剖析和展示ephrin领域出现的独特研究优势，促进协同合作; 4）出版会议记录，作为向普通癌症生物学受众通报这一竞技场进展的一种手段; 5）促进代表性不足的少数群体或来自贫困背景的个人参与健康科学研究。

DESCRIPTION (provided by applicant): The emerging understanding of the function of ephrins and their ligands raises the prospect of new insights to developmental and cancer biology. Recently, for cancers of the colon, prostate, stomach, esophagus, lung, breast, neuroblastoma, brain tumor, and melanoma, ephrin aberrations are reported, and linked to transformation or progression of malignant behaviors. The varied domains of expertise in biology and pathology, as well as molecular, genetics, genomics, and experimental Pharmaceuticals being applied to understand the role and utility of ephrins as mediators of normal cell function or as targets to treat cancer argue for a central coordinated gathering of researchers from these disparate disciplines and fields to share information, to develop synergistic collaborations, and to identify gaps and bridges to accelerated progress. A sustained, multi-year, annual meeting is esteemed to be an optimal strategy by which to affect building broader connectivity, more comprehensive appreciation for the different aspects of the field, and to demonstrate enhanced productivity in the biology, pathology, and pharmacology of ephrins. The aims of the annual "Ephrins and Cancer" meetings are: 1) to host a multidisciplinary meeting that brings the leading thinkers of ephrin biology to a focused gathering for updates on the science; 2) to target strategic invitees to fill "gaps" in aspects of ephrin biology related to cancer processes; 3) to promote synergistic collaborations through exposure, profiling, and demonstration of unique research strengths emerging in the ephrin field; 4) to publish proceedings from the meetings as a means of apprising the general cancer biology audience of advances in this arena; and 5) to promote engagement by underrepresented minorities or individuals from underprivileged backgrounds in health science research.