Ephrins and Cancer

描述(由申请人提供)：对肾上腺素及其配体的功能的新理解提高了对发育和癌症生物学的新见解的前景。最近，在结肠癌、前列腺癌、胃癌、食道癌、肺癌、乳腺癌、神经母细胞瘤、脑肿瘤和黑色素瘤等肿瘤中，有报道称ePhin基因异常与恶性行为的转化或进展有关。生物学和病理学的不同专业领域，以及分子、遗传学、基因组学和实验药剂学正在被应用于理解eSpein作为正常细胞功能的介体或作为治疗癌症的靶点的作用和效用，要求来自这些不同学科和领域的研究人员集中协调地聚集在一起，共享信息，发展协同合作，并找出差距和加快进展的桥梁。持续的、多年的年度会议被认为是影响建立更广泛的连通性、对该领域不同方面进行更全面的评价、并展示提高肾上腺素的生物学、病理学和药理学生产力的最佳战略。一年一度的“电子短语与癌症”会议的目标是：1)主办一次多学科会议，将电子短语生物学的主要思想家聚集在一起，以获取科学的最新进展；2)针对战略受邀者，填补与癌症过程相关的电子短语生物学方面的“空白”；3)通过曝光、简介和展示电子短语领域出现的独特研究优势，促进协同合作；4)出版会议记录，作为向普通癌症生物学受众通报该领域进展的一种手段；以及5)促进代表不足的少数群体或来自贫困背景的个人参与健康科学研究。

DESCRIPTION (provided by applicant): The emerging understanding of the function of ephrins and their ligands raises the prospect of new insights to developmental and cancer biology. Recently, for cancers of the colon, prostate, stomach, esophagus, lung, breast, neuroblastoma, brain tumor, and melanoma, ephrin aberrations are reported, and linked to transformation or progression of malignant behaviors. The varied domains of expertise in biology and pathology, as well as molecular, genetics, genomics, and experimental Pharmaceuticals being applied to understand the role and utility of ephrins as mediators of normal cell function or as targets to treat cancer argue for a central coordinated gathering of researchers from these disparate disciplines and fields to share information, to develop synergistic collaborations, and to identify gaps and bridges to accelerated progress. A sustained, multi-year, annual meeting is esteemed to be an optimal strategy by which to affect building broader connectivity, more comprehensive appreciation for the different aspects of the field, and to demonstrate enhanced productivity in the biology, pathology, and pharmacology of ephrins. The aims of the annual "Ephrins and Cancer" meetings are: 1) to host a multidisciplinary meeting that brings the leading thinkers of ephrin biology to a focused gathering for updates on the science; 2) to target strategic invitees to fill "gaps" in aspects of ephrin biology related to cancer processes; 3) to promote synergistic collaborations through exposure, profiling, and demonstration of unique research strengths emerging in the ephrin field; 4) to publish proceedings from the meetings as a means of apprising the general cancer biology audience of advances in this arena; and 5) to promote engagement by underrepresented minorities or individuals from underprivileged backgrounds in health science research.