Oral-Based Diagnostics

描述(申请人提供)：纽约科学院计划于2006年10月10日至13日在佐治亚州亚特兰大郊外拉尼尔湖上的Emerald Pointe度假村举行一次名为“基于口腔的诊断”的大型科学会议。这次会议由纽约大学牙科学院基础科学教授Daniel Malamud博士和利哈伊大学化学教授R.Sam Niedbala博士组织。基于口腔的诊断有可能检测到系统性疾病和接触各种有害物质的证据，并提供健康和疾病状况的生物标记物。口腔诊断新方法的整合正在扩大，包括基因组学、蛋白质组学、生物信息学和纳米技术。诊断技术的改进带来了更“用户友好”的方法。从市场上出现的几种新的基于口腔的诊断产品可以看出，最近在口腔诊断学领域将工作台分析转化为商业产品的努力有所增加。在这一领域，学术、政府和行业的合作关系也正在形成，所有这些无疑都将有助于该领域的快速发展。这次研讨会的目的之一是聚集毒理学、病理学、口腔生物学、牙科研究和临床医学领域的领导者，讨论口腔诊断学领域的进展，并允许发起新的合作。这次会议的一个成果将是编制这一领域出版物的书目；第二个成果将是记录会议记录的《纽约科学院年鉴》卷。除了口腔和全身疾病的诊断外，唾液和其他口腔液体的分析还可以非侵入性地检测暴露在环境毒素、生物恐怖主义和化学战以及滥用物质中的物质。此外，口腔液提供了疾病状态的生物标志物，包括心血管疾病、内分泌紊乱、自身免疫性疾病、癌症和许多传染病。本次会议将集中讨论口腔诊断学领域的进展和新技术，以及它们在检测健康状况方面的效用。

DESCRIPTION (provided by applicant): The New York Academy of Sciences is planning a major scientific conference entitled, "Oral- Based Diagnostics," to be held from October 10-13, 2006 at the Emerald Pointe Resort on Lake Lanier, GA, outside Atlanta. The conference is being organized by Daniel Malamud, Ph.D., Professor of Basic Sciences, New York University College of Dentistry and R. Sam Niedbala, Ph.D., Professor of Chemistry, Lehigh University. Oral-based diagnostics have the potential to detect systemic disease and evidence of exposure to various harmful substances, as well as provide biomarkers of health and disease status. Integration of novel approaches to oral based diagnostics is expanding to include genomics, proteomics, bioinformatics and nanotechnology. Improved technologies for diagnostics are resulting in more "user-friendly" methods. Efforts to translate bench assays to commercial products in the area of oral diagnostics have increased recently as witnessed by the appearance of several new oral based diagnostic products in the market place. Collaborative academic, government and industry relationships in this arena are also forming all of which will undoubtedly serve to rapidly advance the field. One of the aims of this symposium is to bring together leaders in the areas of toxicology, pathology, oral biology, dental research, and clinical medicine to discuss advances in the field of oral diagnostics, and to permit the initiation of new collaborations. One outcome of this conference will be the compilation of a bibliography of publications in this area; a second will be the volume of the Annals of the NY Academy of Sciences, documenting the proceedings of the conference. In addition to diagnosis of oral and systemic diseases, analysis of saliva and other oral fluids permits non-invasive detection of exposure to environmental toxins, agents of bioterrorism and chemical warfare, as well as substances of abuse. Moreover, oral fluids provide biomarkers of disease status including those for cardiovascular disease, endocrine disorders, autoimmune diseases, cancer, and many infectious diseases. This conference will focus on advances and new technologies in the oral diagnostics field and their utility for detection of health status.