ANIMAL RESOURCES FACILITY EQUIPMENT IMPROVED PROJECT

描述（由申请人提供）： 乔斯林糖尿病中心致力于继续改善其动物护理和使用计划。最近完成的翻修大大改善了动物护理，改善了物理设备、笼子清洗能力和动物饲养条件。增加一名全职兽医主任也加强了该计划，特别是在动物健康、方案制定和财政稳定方面。该改进项目将支持乔斯林糖尿病中心的努力，通过提高动物福利和动物设施的有效运作，继续为研究人员提供优质的研究资源。所述目标要求增加PIV小鼠架，升级静态鼠微隔离笼，为大鼠提供完整的微隔离系统，为所有饮用水提供水净化系统，并为手术室提供层流工作站。大鼠和小鼠是Joslin糖尿病中心动物设施中饲养的唯一物种，上述改进将通过提供更高的生物安全性、更高质量的水、更健康的动物微环境和人员宏观环境以及使动物更容易监测的静态笼来影响它们的福利。积极追求改善动物护理的短期目标对于实现AAALAC的长期目标至关重要;国际认证。乔斯林糖尿病中心的研究项目经历了显著的扩展，由于目前II型糖尿病的流行，预计这一趋势将继续下去。由于转基因和基因敲除技术的强大工具，动物模型（主要是鼠模型）得到了极大的扩展。所要求的改进不仅会影响动物福利，而且还将有利于研究动物计划的效率。

DESCRIPTION (provided by applicant): The Joslin Diabetes Center is committed to the continued improvement of its animal care and use program. Recently completed renovations have greatly improved animal care by providing improvements in the physical plant, cage wash capabilities and animal housing. The addition of a full time Veterinarian Director has also strengthened the program, especially with regards to animal health, protocol development and fiscal stability. This improvement project will support the efforts of the Joslin Diabetes Center to continue the process of providing investigators with a quality research resource by enhancing animal welfare and the efficient operation of the animal facility. The described aims request additional PIV mouse racks, upgrading static murine micro-isolation cages, a full micro-isolation system for rats, a water purification system for all drinking water, and a laminar flow work station for a procedure room. Rats and mice are the only species housed in the Joslin Diabetes Center animal facility and the above improvements will impact their welfare by providing greater biosecurity, higher quality water, a healthier microenvironment for the animals and macrooenvironment for personnel, and static cages which allow animals to be more easily monitored. Aggressive pursuit of the short-term goals of improving animal care is critical to achieving the long-term goal of AAALAC; International accreditation. The research program at the Joslin Diabetes Center has experienced significant expansion and is expected to continue this trend due to the current epidemic of Type II diabetes. Animal models, primarily murine, have been enormously expanded as a result of the powerful tools of transgenic and knockout technologies. Not only will the requested improvements impact animal welfare, but they will also benefit the efficiency of the research animal program.