INFLAMMATORY RESPONSE TO DIETS BETWEEN ASIANS AND CAUCASIANS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项研究的假设是，与高加索人相比，亚裔美国人从传统的亚洲饮食转变为典型的美国饮食时，发生促炎状态的风险更高，这可能会导致心脏病和糖尿病的发展。这些炎症反应将通过单核细胞的激活来反映，如已知的单核细胞激活剂蛋白激酶C的测定。这是假设，这些炎症反应中的牙龈沟液将反映类似的变化，这些标记物在血浆和单核细胞。这项研究的具体目的是比较远东裔美国人和高加索裔美国人从传统的亚洲饮食转变为典型的美国饮食时，单核细胞中初级PKC激活的炎症反应，并将血浆和单核细胞中炎症反应的生化变化与牙周沟液中的炎症反应相关联。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The hypothesis of this study is that Asian Americans compared to Caucasians, will be at higher risk of developing a pro-inflammatory state that may contribute to the development of heart disease and diabetes when they change from a traditional Asian diet to a typical American diet. These inflammatory responses will be reflected by the activation of monocytes as measured by protein kinase C (PKC), a known activator of monocytes. It is hypothesized that these inflammatory responses in the gingival crevicular fluid (GCF) will reflect similar changes of these markers in the plasma and monocytes. The specific aims of this study are to compare the inflammatory responses (primary PKC activation in monocytes), between Far-East Asian Americans and Caucasian Americans, when they change from a traditional Asian diet to a typical American diet and also to correlate the biochemical changes of inflammatory responses in the plasma and monocytes with those in the gingival crevicular fluid.