RENOVATIONS FOR AUTOCLAVE SUPPORT SERVICE

描述(由申请人提供)： 该项目的总体目标是为石溪大学(SBU)转基因、SCID、基因敲除、免疫受损和无病原体小鼠的使用提供支持和关怀。该机构有改善教职员工动物护理和服务的短期和长期目标。这笔赠款将购买设备，并对设备安装进行小规模翻新，以升级健康科学中心-实验动物资源部的高压灭菌器支持服务。18个基础和临床应用研究实验室，从事基因识别、定位、分析和调控；细菌和病毒受体调节；靶向基因治疗；传染病发病机制；肿瘤学；脑淀粉样血管病；疫苗开发；以及膜运输等研究，目前收容了需要消毒设备的最大隔离啮齿动物。 这笔赠款将购买一个99立方米。FT，双门高压灭菌器和两个清洁的蒸汽发生器。设备安装需要对现有的高压灭菌器和机械支持区域进行小规模翻新。这种支持设备将改善对无病原体动物的护理，并通过为最大限度地隔离提供基本的灭菌设备来满足不断扩大的研究项目需求，并通过集中高压灭菌服务来降低动物护理人员的职业健康风险和劳动力成本。

DESCRIPTION (provided by applicant): The general objective of this project is to provide support and care for the use of transgenic, SCID, knockout, immunocompromised and pathogen free mice at the Stony Brook University (SBU). The institution has both short term and long-term goals to improve animal care and services for the faculty. This grant will purchase equipment, and perform minor renovations for equipment installation, to upgrade autoclave support services in the Health Sciences Center - Division of Laboratory Animal Resources. Eighteen basic and clinically applied research laboratories, who conduct research in gene identification, mapping, analysis and regulation; bacterial and viral receptor regulation; targeted gene therapy; infectious disease pathogenesis; oncology; cerebral amyloid angiopathy; vaccine development; and membrane transport, currently house maximum isolation rodents who require sterilized equipment. The grant will purchase one 99 cu. ft, double door autoclave and two clean steam generators. Minor renovations in existing autoclave and mechanical support areas are required for equipment installation. This support equipment will improve the care of pathogen free animals and address expanding research program needs by providing essential sterilized equipment for maximum isolation housing and reducing occupational health risks and labor costs for animal care personnel through centralization of autoclaving service.