Neural correlates of memory fMR in human cortex.

描述（由申请人提供）： 该提案的总体目标是建立在相同的认知措施，在相同的网站，在人类联合皮层相同的主题与功能磁共振成像（fMR）和神经元的活动变化获得的BOLD信号的变化之间的关系。该提案利用了一个独特的临床机会，患者接受手术治疗癫痫的技术，他们在局部麻醉下清醒的一部分操作。在这种情况下，我们以前记录的神经元活动，动作电位（AP）和覆盖脑电图（ECoG）从侧颞叶联合皮层在最近的文字记忆，发现相当大比例的神经元改变了AP活动的频率与该任务。fMR文献和我们的初步fMR数据显示，最近的记忆措施，在颞叶外侧皮层的fMR变化。最近开发了一种适用于fMR和术中记录的言语记忆测量方法，我们建议调查AP，局部场电位（LFP），ECoG和fMR之间的空间和时间关系。有待检验的假设包括fMR和LFP之间的关系比AP活动更密切，根据非人类研究报告的结果，以及fMR变化对记忆过程中AP活动持续模式的位点的特异性。这些研究提供了一个独特的窗口，了解神经活动如何反映在更高水平的认知测量过程中BOLD fMR的变化中。

DESCRIPTION (provided by applicant): The overall aim of this proposal is to establish the relationships between changes in BOLD signals obtained with functional magnetic resonance imaging (fMR) and changes in activity of neurons during the same cognitive measures, at the same sites, in the same subjects in human association cortex. The proposal utilizes a unique clinical opportunity, patients undergoing surgery for epilepsy with a technique where they are awake under local anesthesia for a portion of the operation. In that context we have previously recorded neuronal activity, both action potentials (AP) and overlying electroencephalogram (ECoG) from lateral temporal association cortex during recent verbal memory, finding that a substantial proportion of neurons changed the frequency of AP activity with that task. Both the fMR literature and our preliminary fMR data show fMR changes in lateral temporal cortex with recent memory measures. Having developed a recent verbal memory measure suitable for both fMR and intraoperative recording, we propose investigating the spatial and temporal relation between AP, local field potential (LFP), ECoG and fMR. Hypotheses to be tested include a closer relation between fMR and LFP than AP activity, based on findings reported from nonhuman studies, and specificity of fMR changes to sites with sustained patterns of AP activity during memory. These studies provide a unique window into how neural activity is reflected in changes in BOLD fMR during higher-level cognitive measures.