Rochester Epidemiology Project

描述(由申请人提供)：此竞争性续签申请请求继续为罗切斯特流行病学项目(REP)提供核心支持，该项目是为明尼苏达州奥姆斯特县居民的医疗保健提供者提供的医疗记录链接系统。这一独特的数据资源记录了从20世纪初S到现在为社区居民提供的医疗服务，并支持对几乎每个研究设计和发生在这个国家的大多数疾病实体进行基于人群的流行病学调查。该代表支持了梅奥诊所和其他学术机构的大量研究人员的工作，这些机构允许对具有重大社会影响的疾病进行有效的外部支持研究，包括25项R01和其他研究资助，6项计划项目/中心资助和17项奖学金/培训资助。自40年前首次获得资助以来，基于该代表的1500多篇手稿已发表在同行评议文献中，其中包括自四年前我们上次竞争性更新以来的351篇。这些来自地理上定义的人口的广泛数据在这个国家几乎是无与伦比的，这一重要的研究资源必须得到保存和不断更新。 这笔赠款的每一个周期不仅提供了维持核心记录联系功能的机会，而且也提供了加强其效用的机会。在我们的下一个项目周期中，我们提议通过继续清点奥姆斯特德县人口并将其与医疗事件联系起来来更新数据资源(目标1)；整理可用于加强遗传学研究的信息，例如是否存在已存档的生物标本、基因多态分布和出生证明信息(目标2)以及加强数据安全和改善对REP最终用户的后勤支持(目标3)。这是在我们在上一个供资期间取得的成就的基础上取得的，这些成就包括更好地及时收集数据、增加新的信息来源以及开发工具以提高获取的便利性，同时提供更大的数据安全。因此，为下一个供资周期计划的努力将为越来越多的临床研究人员提供更多的数据，他们与流行病学家、统计学家和基础科学家组成的多学科团队一起，利用新的科学来解决重大问题，目标是将发现转化为改善医疗实践和改善人口健康的目标，如国家卫生研究院路线图所述。

DESCRIPTION (provided by applicant): This competitive renewal application requests continuation of core support for the Rochester Epidemiology Project (REP), the medical record linkage system for health care providers to residents of Olmsted County, Minnesota. This unique data resource chronicles the medical care delivered to community residents from the early 1900's to the present and has supported population-based epidemiologic investigations of virtually every study design and of most disease entities occurring in this country. The REP has supported the work of a large number of investigators at Mayo Clinic and other academic institutions permitted the efficient conduct of extramurally-supported studies of conditions with substantial societal impact, including 25 R01 and other research grants, 6 program project/center grants and 17 fellowship/training grants. Since first funded 40 years ago, more than 1,500 manuscripts based on the REP have been published in the peer-reviewed literature, including 351 since our last competitive renewal four years ago These extensive data from a geographically-defined population are virtually unparalleled in this country, and it is essential that this important research resource be preserved and continually updated. Each cycle of this grant has presented an opportunity to not only maintain the core record linkage function, but to enhance its utility as well. For our next project cycle, we propose to update the data resources through the continued enumeration of the population of Olmsted County and linking them with medical events (Aim 1); collate information that can be used to augment genetic studies such as the existence of archived biologic specimens, distributions of genetic polymorphisms and birth certificate information (Aim 2) and enhancing data security and improving logistical support for end-users of the REP (Aim 3). This builds on our accomplishments from the previous funding period that include better timeliness of data collection, addition of new sources of information, and development of tools to increase ease of access while providing greater data security. Thus, the efforts planned for this next funding cycle will provide increased data availability for the growing pool of clinical investigators who, in conjunction with multidisciplinary teams of epidemiologists, statisticians and basic scientists, are exploiting the new sciences to address significant questions with a goal of translating findings into improved medical practice and better health for the population as outlined in the NIH Road Map.