Theoretical Population Genetics

描述（由申请人提供）：本修订项目涉及开发新的种群遗传数据统计方法。重点将集中在三个主要领域：群体结构的表征，遗传标记内部和之间以及沿单倍型的关联模式的表征，以及两个以上等位基因组的身份状态的表征。理论的发展至少在一定程度上是为了满足目前对人类和其他物种进行大规模SNP调查的需要。

DESCRIPTION (provided by applicant): This revised project is concerned with developing new statistical methodology for population genetic data. Attention will be focused on three main areas: the characterization of population structure, the characterization of the association patterns within and between genetic markers and along haplotypes, and the characterization of the identity status of sets of more than two alleles. Theory will be developed at least in part in response to the needs of current large-scale SNP surveys of humans and other species. Specific topics include determining the sampling properties of population-specific measures of population structure and the comparison of marker- and trait-based estimates of population structure. A comparison will be conducted of current methods for defining haplotype blocks, and consideration of alternative methods based on diversity or on contingency-table and regression analyses of one marker versus haplotypes of subsequent markers. The means for drawing inferences about associations among more than two alleles at one locus, or among single alleles taken from multiple loci will be developed.