Decarboxylative fluorination of aromatic carboxylic acids

目的：本项目将研究通过C-H和脱羧活化合成含氟芳香族化合物的方法，方法：利用分子中羧酸官能团的反应活性，开发新型含氟芳香族化合物的合成试剂，设计一系列含氟芳香族化合物，并进行合成和测试。成功的试剂将被进一步研究，以揭示它们的范围和潜力，以及它们在工业相关化合物中的应用，特别是在制药竞技场。Remit：该项目福尔斯催化和合成有机化学领域

Objective:This project will investigate the development of synthetic methods for the synthesis of fluorinated aromatic compounds via C-H and decarboxylative activation.Approach:We will develop novel fluorinating reagents capable of achieving fluorination aromatic compounds by taking advantage of the reactivity of carboxylic acid functional groups present in the molecules.A series of fluorinating reagents will be designed with the help of computational studies, synthesized and tested. Successful reagents will be further investigated to reveal their scope and potential as well as their applications to industrially relevant compounds, particularly in the pharmaceutical arena.Remit:This project falls within the areas of Catalysis and Synthetic Organic Chemistry