Novel enzymatic modifications of polysaccharides for new health and personal care products

在这个跨学科的项目中，我们建议使用组学技术、生物信息学和分子生物学来发现高效的甲壳素/壳聚糖转化酶，以提供具有更好材料性能的“天然”材料，进一步扩大它们作为固有可持续家居产品添加剂的用途。学生将进行实验，使用最先进的细菌和酵母表达系统来生产这些酶的重组形式。将与纽卡斯尔诺森布里亚大学应用科学系的贾斯汀·佩里教授合作，研究目标蛋白对甲壳素/壳聚糖的生化作用，以及这些蛋白如何调整其材料性质。

In this interdisciplinary project, we propose to use 'omics technologies, bioinformatics and molecular biology to discover highly performing chitin/chitosan transforming enzymes to provide 'natural' materials with improved material properties further widening their use as inherently sustainable home product additives. The student will undertake experiments to produce recombinant forms of these enzymes using state of the art bacterial and yeast expression systems. Target proteins will be studied for their biochemical action on chitin/chitosan and how these adapt their material properties in collaboration with Prof Justin Perry in the Department of Applied Sciences at Northumbria University, Newcastle.