Compare and contrast effects of allergen exposure via skin and airway epithelial barriers on exosome production and subsequent immune responses

I型超敏反应或过敏性免疫反应的定义是诱导抗原特异的Th2细胞和IgE抗体的产生，涉及在过敏原暴露期间激活免疫系统的适应性手臂。上皮细胞是防止过敏原接触的第一道防线，上皮细胞与过敏原的相互作用已被确定为过敏致敏不良结果途径中的第一个关键事件之一，也是未来研究的一个关键领域。本博士将研究皮肤和呼吸道上皮表面在暴露于不同过敏原后影响免疫结果的作用。

Type I hypersensitivities, or allergic immune responses, are defined by the induction of antigen-specific Th2 cells and IgE antibody production, involving activation of the adaptive arm of the immune system during allergen exposure. Epithelial cells are one of the first lines of defence against allergen contact and epithelial cell-allergen interactions have been identified as one of the first key events in the adverse outcome pathway for allergic sensitisation and a key area of focus for future research. This PhD will examine the role of skin and airway epithelial surfaces in influencing the immune outcome after exposure to different allergens.